US 12,269,802 B2
Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl] amino] acetic acid
Boris I. Gorin, Oakville (CA); Christopher M. Lanthier, Burlington (CA); Anne Buu Chau Luong, Mississauga (CA); James Densmore Copp, Bargersville, IN (US); Javier Gonzalez, Lafayette, IN (US); Sascha Jautze, Piscataway, NJ (US); Erich Kraus, Essen (DE); and Alan O'Connor, Piscataway, NJ (US)
Assigned to Akebia Therapeutics, Inc., Cambridge, MA (US)
Filed by Akebia Therapeutics, Inc., Cambridge, MA (US)
Filed on Jun. 13, 2023, as Appl. No. 18/334,101.
Application 18/334,101 is a division of application No. 17/053,614, granted, now 11,713,298, previously published as PCT/US2019/031310, filed on May 8, 2019.
Claims priority of provisional application 62/669,135, filed on May 9, 2018.
Prior Publication US 2024/0158354 A1, May 16, 2024
Int. Cl. C07D 213/81 (2006.01)
CPC C07D 213/81 (2013.01) 17 Claims
 
1. A compound of Formula (I):

OG Complex Work Unit Chemistry
or a salt thereof, wherein:
R1 is C1-4 alkyl, CH2Cl, phenyl, or benzyl, in which each of phenyl and benzyl may be independently substituted with one, two or three substituents selected from methyl, methoxy, nitro and halogen; and
R2 is C1-4 alkyl; and
wherein the compound comprises less than about 0.5% of the compound of Formula (5):

OG Complex Work Unit Chemistry