US 12,269,793 B2
Affinity illudofulvene conjugates
Michael Kelner, San Diego, CA (US)
Assigned to AF CHEMICALS, LLC, San Diego, CA (US)
Filed by AF Chemicals, LLC, San Diego, CA (US)
Filed on Feb. 27, 2023, as Appl. No. 18/175,495.
Application 18/175,495 is a continuation of application No. 17/103,780, filed on Nov. 24, 2020, granted, now 11,591,295.
Claims priority of provisional application 63/116,772, filed on Nov. 20, 2020.
Claims priority of provisional application 62/940,096, filed on Nov. 25, 2019.
Claims priority of application No. 20 209 541 (EP), filed on Nov. 24, 2020.
Prior Publication US 2023/0212113 A1, Jul. 6, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07C 317/44 (2006.01); A61K 31/215 (2006.01); A61K 31/255 (2006.01); A61K 31/265 (2006.01); A61K 31/27 (2006.01); A61K 31/4015 (2006.01); A61K 38/05 (2006.01); A61K 38/06 (2006.01); A61K 47/54 (2017.01); C07C 205/42 (2006.01); C07C 225/14 (2006.01); C07C 271/34 (2006.01); C07C 309/72 (2006.01); C07C 311/16 (2006.01); C07D 207/444 (2006.01); C07K 5/062 (2006.01); C07K 5/083 (2006.01)
CPC C07C 317/44 (2013.01) [A61K 31/215 (2013.01); A61K 31/255 (2013.01); A61K 31/265 (2013.01); A61K 31/27 (2013.01); A61K 31/4015 (2013.01); A61K 38/05 (2013.01); A61K 38/06 (2013.01); A61K 47/554 (2017.08); C07C 205/42 (2013.01); C07C 225/14 (2013.01); C07C 271/34 (2013.01); C07C 309/72 (2013.01); C07C 311/16 (2013.01); C07D 207/444 (2013.01); C07K 5/06026 (2013.01); C07K 5/06052 (2013.01); C07K 5/0806 (2013.01); C07C 2603/94 (2017.05)] 20 Claims
 
1. A compound of the formula:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, where R1 and R2 each independently represent —H, -, —OH, —OCH3, —OC(═O)CH3—CH3, —CH2—CH3, —CH—(CH3)2, —C(CH3)3, —CH2—CH2—CH3, —CH2—CH—(CH3)2, —CH—C—(CH3)3, —C(═O)CH3, —CH2OH, and —(C1-C4) alkyl.