US 12,269,034 B2
Vacuum-assisted drying of filters in microfluidic systems
Hojjat Madadi, Newcastle upon Tyne (GB); Robin Page, Newcastle upon Tyne (GB); Molly Rose Jowsey, Newcastle upon Tyne (GB); Thomas Michael Willshare, Newcastle upon Tyne (GB); and Roberts Rimsa, Newcastle upon Tyne (GB)
Assigned to QUANTUMDX GROUP LIMITED, Newcastle Upon Tyne (GB)
Appl. No. 17/298,241
Filed by QuantuMDx Group Limited, Newcastle upon Tyne (GB)
PCT Filed Nov. 28, 2019, PCT No. PCT/GB2019/053362
§ 371(c)(1), (2) Date May 28, 2021,
PCT Pub. No. WO2020/109798, PCT Pub. Date Jun. 4, 2020.
Claims priority of application No. 1819417 (GB), filed on Nov. 29, 2018.
Prior Publication US 2022/0118451 A1, Apr. 21, 2022
Int. Cl. B01L 3/00 (2006.01); A47L 15/42 (2006.01); A61L 27/16 (2006.01); A61L 27/56 (2006.01); B01F 23/00 (2022.01); B01F 23/41 (2022.01); B01F 101/23 (2022.01); B01L 7/00 (2006.01); B01L 9/00 (2006.01); B23Q 17/24 (2006.01); C07K 14/705 (2006.01); C08F 220/56 (2006.01); C12M 1/34 (2006.01); C12Q 1/04 (2006.01); C12Q 1/18 (2006.01); C12Q 1/6844 (2018.01); C12Q 1/686 (2018.01); G01N 1/31 (2006.01); G01N 21/17 (2006.01); G01N 21/3577 (2014.01); G01N 21/359 (2014.01); G01N 21/39 (2006.01); G01N 21/45 (2006.01); G01N 21/64 (2006.01); G01N 21/77 (2006.01); G01N 21/78 (2006.01); G01N 27/414 (2006.01); G01N 30/12 (2006.01); G01N 30/68 (2006.01); G01N 30/70 (2006.01); G01N 30/72 (2006.01); G01N 30/88 (2006.01); G01N 33/00 (2006.01); G01N 33/18 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/543 (2006.01); G01N 33/68 (2006.01); G01N 33/74 (2006.01); G01N 35/00 (2006.01); G01N 35/04 (2006.01); G01N 35/10 (2006.01); G06T 7/00 (2017.01); G06T 7/90 (2017.01); G16H 20/60 (2018.01); G16H 40/63 (2018.01); H10K 10/46 (2023.01); H10K 85/00 (2023.01); H10K 85/20 (2023.01)
CPC B01L 3/502753 (2013.01) [B01L 3/50273 (2013.01); B01L 2200/0621 (2013.01); B01L 2300/0681 (2013.01); B01L 2300/0816 (2013.01); B01L 2400/0481 (2013.01); B01L 2400/0633 (2013.01)] 26 Claims
OG exemplary drawing
 
1. A microfluidic device with a fluidic channel, comprising:
a filter positioned within a sealable portion of the fluidic channel,
a valve configured to releasably seal the sealable portion of the fluidic channel which contains the filter therein, and
a displacement pump in the sealable portion of the fluidic channel, the displacement pump being configured to displace a volume greater than a volume of the sealable portion and configured to reduce a pressure in said sealable portion of the fluidic channel which contains the filter therein, wherein the displacement pump is configured to substantially simultaneously draw fluid through or over the filter, and is configured to reduce the pressure in said sealable portion of the fluidic channel containing the filter;
wherein the filter divides the sealable portion into a first volume between said valve and the filter and a second volume between the displacement pump and the valve, wherein the first volume is smaller than the second volume, and
wherein a volume of the fluidic channel downstream of the valve is larger than the volume of the sealable portion.