US 12,269,001 B2
Flow channel structure and lipid particle or micelle formation method using same
Manabu Tokeshi, Sapporo (JP); Masatoshi Maeki, Sapporo (JP); Yusuke Sato, Sapporo (JP); and Hideyoshi Harashima, Sapporo (JP)
Assigned to National University Corporation Hokkaido University, Sapporo (JP)
Appl. No. 16/605,138
Filed by National University Corporation Hokkaido University, Sapporo (JP)
PCT Filed Apr. 13, 2018, PCT No. PCT/JP2018/015550
§ 371(c)(1), (2) Date Oct. 14, 2019,
PCT Pub. No. WO2018/190423, PCT Pub. Date Oct. 18, 2018.
Claims priority of application No. JP2017-080118 (JP), filed on Apr. 13, 2017.
Prior Publication US 2021/0129103 A1, May 6, 2021
Int. Cl. B01J 13/04 (2006.01); A61K 9/127 (2006.01); A61K 9/1277 (2025.01); B01J 19/00 (2006.01); B82Y 5/00 (2011.01)
CPC B01J 13/04 (2013.01) [A61K 9/1277 (2013.01); B01J 19/0093 (2013.01); B01J 2219/0086 (2013.01); B01J 2219/00894 (2013.01); B01J 2219/00959 (2013.01); B82Y 5/00 (2013.01)] 23 Claims
OG exemplary drawing
 
1. A flow channel structure for forming nano-sized lipid particles or micelles,
wherein in the flow channel structure, a mutually independent first inlet channel that introduces a first fluid and a second inlet channel that introduces a second fluid join together and have respectively fixed lengths on the upstream side thereof and a single dilution flow channel is formed towards the downstream side thereof,
the dilution flow channel has a bent flow channel site that is bent two-dimensionally in at least a portion thereof, and
the bent flow channel site is such that,
in the case the axial direction of the dilution flow channel upstream therefrom or the direction in which it extends is defined as the X direction, the widthwise direction of the dilution flow channel that perpendicularly intersects with this X direction is defined as the Y direction, and the flow channel width of the dilution flow channel upstream therefrom is defined as y0,
at least two or more structural elements, which define flow channel width of the dilution flow channel by alternately protruding from both side surfaces of the dilution flow channel in opposition to the Y direction towards the center of the flow channel at a specific height h1, h2, . . . of 1/2y0 or more and less than 1y0 in an approximate Y direction (approximate +Y direction or approximate −Y direction) and at a specific width x1, x2, . . . in the X direction, are provided at specific intervals d1, d2, . . . , wherein the flow channel width y0 is 100 μm to 200 μm, the height of each structural element h1, h2, . . . is 1/2y0 or more than 3/4y0 or less, the width of each structural element x1, x2, . . . is 70 μm to 100 μm, and the interval between each structural element d1, d2, . . . is 100 μm to 500 μm.