| CPC A61N 5/1045 (2013.01) [A61N 5/1036 (2013.01); A61N 5/1049 (2013.01); A61N 5/1031 (2013.01); A61N 2005/1032 (2013.01); A61N 2005/1035 (2013.01); A61N 5/1039 (2013.01); A61N 2005/1041 (2013.01); A61N 5/1077 (2013.01)] | 20 Claims |

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1. A method for delivering radiation treatment to a subject using a radiation delivery device that includes a plurality of components, the plurality of components including one or more first components and one or more second components, the one or more first components including at least one of a collimator or multi-leaf collimator leaves, the one or more second components at least including a couch and a gantry, the method comprising:
defining a preliminary trajectory including a plurality of control points, the preliminary trajectory being defined by a position parameter of each second component for each control point without defining a position parameter of each first component for each control point, the position parameter of each second component for each control point is determined based on a position, a shape, and a size of a region of interest;
generating a treatment plan by optimizing, for each of the plurality of control points, the position parameter of each first component and an intensity;
decomposing the treatment plan into a delivery trajectory including the plurality of control points, each of the plurality of control points being further associated with the optimized intensity, the optimized position parameter of each first component, and a motion parameter of each second component; and
instructing the radiation delivery device to deliver the treatment plan to the subject according to the delivery trajectory.
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