US 12,268,895 B2
Joint optimization of radionuclide and external beam radiotherapy
Peter Demetri Olcott, Los Gatos, CA (US); Michael Kirk Owens, North Easton, MA (US); and Debashish Pal, Sunnyvale, CA (US)
Assigned to RefleXion Medical, Inc., Hayward, CA (US)
Filed by RefleXion Medical, Inc., Hayward, CA (US)
Filed on Apr. 14, 2023, as Appl. No. 18/301,085.
Application 18/301,085 is a continuation of application No. 17/158,848, filed on Jan. 26, 2021, granted, now 11,654,300.
Claims priority of provisional application 62/966,997, filed on Jan. 28, 2020.
Prior Publication US 2023/0405359 A1, Dec. 21, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 5/10 (2006.01)
CPC A61N 5/1031 (2013.01) [A61N 5/1039 (2013.01); A61N 5/1045 (2013.01); A61N 2005/1024 (2013.01); A61N 2005/1034 (2013.01); A61N 2005/1098 (2013.01)] 28 Claims
OG exemplary drawing
 
1. A method for joint internal and external radiotherapy, the method comprising:
generating a radiotherapy treatment plan that specifies a radiation dose deliverable using an internal therapeutic radiation source (ITRS) and a radiation dose deliverable using an external therapeutic radiation source (ETRS), wherein the ITRS radiation dose and the ETRS radiation doses have been calculated by iterating through intermediate values of the ITRS radiation dose and intermediate values of the ETRS radiation dose to attain a cumulative radiation dose that meets prescribed dose requirements;
delivering radiation in a first treatment session to a patient target region using a radiotherapy system comprising an ETRS movable about a patient target region; and
delivering radiation in a second treatment session using an ITRS to the patient target region.