US 12,268,879 B2
Autotitration of therapy using detected electrical activity
Xin Su, Plymouth, MN (US); Thaddeus S. Brink, St. Paul, MN (US); and Dwight E. Nelson, Shoreview, MN (US)
Assigned to Medtronic, Inc., Minneapolis, MN (US)
Filed by Medtronic, Inc., Minneapolis, MN (US)
Filed on Sep. 10, 2021, as Appl. No. 17/472,139.
Application 17/472,139 is a continuation of application No. 16/344,719, granted, now 11,571,575, previously published as PCT/US2017/051441, filed on Sep. 14, 2017.
Claims priority of provisional application 62/414,396, filed on Oct. 28, 2016.
Prior Publication US 2022/0080206 A1, Mar. 17, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 1/36 (2006.01); A61B 5/388 (2021.01); A61N 1/372 (2006.01); G16H 20/30 (2018.01)
CPC A61N 1/36139 (2013.01) [A61B 5/388 (2021.01); A61N 1/36007 (2013.01); A61N 1/36146 (2013.01); A61N 1/37241 (2013.01); A61N 1/36107 (2013.01); G16H 20/30 (2018.01)] 31 Claims
OG exemplary drawing
 
1. A medical system comprising:
an implantable medical device (IMD); and
a lead coupled to the IMD, the lead comprising a plurality of electrodes, the plurality of electrodes comprising at least one stimulation electrode configured to deliver electrical stimulation to a target tissue site of a patient and at least one sensing electrode configured to sense one or more bioelectrical signals from the patient,
wherein the IMD comprises:
a stimulation generator programmed to deliver, via the at least one stimulation electrode, electrical stimulation to the patient according to a plurality of electrical stimulation parameter sets, each electrical stimulation parameter set of the plurality of electrical stimulation parameter sets defining a respective electrical stimulation signal deliverable to the patient; and
one or more processors configured to:
control the stimulation generator to deliver, via the at least one stimulation electrode, electrical stimulation to the target tissue site based on the plurality of electrical stimulation parameter sets;
obtain, via the at least one sensing electrode and for each electrical stimulation parameter set of the plurality of electrical stimulation parameter sets, a respective signal representative of a bioelectrical response corresponding to muscle fiber or nerve activity sensed by the at least one sensing electrode from the patient in response to the electrical stimulation delivered to the patient according to the respective electrical stimulation parameter set;
titrate electrical stimulation to determine, based on the obtained respective signals, a primary electrical stimulation parameter set that defines electrical stimulation therapy deliverable to the patient by the stimulation generator;
control delivery of the electrical stimulation therapy to the patient according to the primary electrical stimulation parameter set;
periodically titrate electrical stimulation to determine, based on the obtained respective signals, a new primary electrical stimulation parameter set that defines electrical stimulation therapy deliverable to the patient by the stimulation generator; and
control delivery of the electrical stimulation therapy to the patient according to the new primary electrical stimulation parameter set.