| CPC A61M 5/3157 (2013.01) [A61M 5/2033 (2013.01); A61M 5/3146 (2013.01); A61M 5/31511 (2013.01); A61M 5/31583 (2013.01); A61M 5/3202 (2013.01); A61M 2205/581 (2013.01); A61M 2205/582 (2013.01)] | 21 Claims |

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1. A drug delivery device comprising:
a drive subassembly comprising a housing and a plunger, wherein the plunger is adapted to be rotated between a locked position, in which the plunger is prevented from advancing, and a released position, in which the plunger is advanceable,
at least one restraining component adapted to restrain rotation of the plunger from the locked position towards the released position, and
a control subassembly comprising a distal region of the housing adapted to receive a syringe and a sleeve coupled to the housing to permit movement of the sleeve relative to the housing to release the plunger;
wherein the at least one restraining component comprises a plunger boss on the plunger and an indent in the housing, the plunger boss having a proximal boss protruding in a proximal direction adapted to be received within the indent to restrain rotation of the plunger from the locked position towards the released position.
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