US 12,268,832 B2
Self-righting systems, methods, and related components
Robert S. Langer, Newton, MA (US); Carlo Giovanni Traverso, Newton, MA (US); Alex G. Abramson, St. Louis, MO (US); Michael Williams, Enterprise, OR (US); and Jacob Wainer, Malden, MA (US)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US); and The Brigham and Women's Hospital, Inc., Boston, MA (US)
Filed by Massachusetts Institute of Technology, Cambridge, MA (US); and The Brigham and Women's Hospital, Inc., Boston, MA (US)
Filed on Dec. 30, 2022, as Appl. No. 18/148,574.
Application 18/148,574 is a continuation of application No. 16/899,644, filed on Jun. 12, 2020, granted, now 11,541,016.
Application 16/899,644 is a continuation in part of application No. 16/614,229, granted, now 11,541,015, previously published as PCT/US2018/033210, filed on May 17, 2018.
Claims priority of provisional application 62/507,653, filed on May 17, 2017.
Claims priority of provisional application 62/507,665, filed on May 17, 2017.
Claims priority of provisional application 62/507,647, filed on May 17, 2017.
Prior Publication US 2023/0218535 A1, Jul. 13, 2023
Int. Cl. A61M 31/00 (2006.01); A61B 5/145 (2006.01); A61B 10/02 (2006.01); A61B 10/06 (2006.01); A61J 3/07 (2006.01); A61K 9/00 (2006.01); A61K 9/48 (2006.01); A61K 38/28 (2006.01); A61M 5/142 (2006.01); A61M 5/145 (2006.01); A61M 5/158 (2006.01); A61M 5/20 (2006.01); A61M 5/32 (2006.01); A61M 37/00 (2006.01); A61N 1/05 (2006.01); A61N 1/32 (2006.01); A61N 1/36 (2006.01)
CPC A61M 31/002 (2013.01) [A61B 5/14503 (2013.01); A61B 5/14539 (2013.01); A61B 10/02 (2013.01); A61J 3/07 (2013.01); A61K 9/0002 (2013.01); A61K 9/0012 (2013.01); A61K 9/0021 (2013.01); A61K 9/0065 (2013.01); A61K 9/0092 (2013.01); A61K 9/4808 (2013.01); A61K 9/4866 (2013.01); A61K 38/28 (2013.01); A61M 5/14276 (2013.01); A61M 5/1454 (2013.01); A61M 5/158 (2013.01); A61M 5/2033 (2013.01); A61M 5/329 (2013.01); A61M 5/3295 (2013.01); A61M 37/0015 (2013.01); A61M 37/0069 (2013.01); A61N 1/325 (2013.01); A61N 1/36007 (2013.01); A61B 2010/0208 (2013.01); A61B 10/0233 (2013.01); A61B 10/06 (2013.01); A61M 2005/14284 (2013.01); A61M 2005/1581 (2013.01); A61M 2005/1585 (2013.01); A61M 2037/0023 (2013.01); A61M 2037/0053 (2013.01); A61M 2205/0238 (2013.01); A61M 2205/21 (2013.01); A61M 2210/1053 (2013.01); A61M 2210/106 (2013.01); A61N 1/0509 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A self-righting article, comprising:
an outer shell and a tissue-engaging surface;
a first pharmaceutical agent disposed within the outer shell; and
a second pharmaceutical agent, different than the first pharmaceutical agent, disposed within the outer shell,
wherein the self-righting article comprises a monostatic body due to a center of mass of the self-righting article and/or a shape of the outer shell, such that the self-righting article has a single stable resting position corresponding to the tissue-engaging surface.