US 12,268,811 B2
Estimation of cardiogenic artefacts on ventilator airway pressure and flow for the automated detection and resolution of patient ventilator asynchronies
Ikaro Garcia Araujo da Silva, Cambridge, MA (US)
Assigned to Koninklijke Philips N.V., Eindhoven (NL)
Filed by KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
Filed on Aug. 17, 2021, as Appl. No. 17/403,913.
Claims priority of provisional application 63/074,550, filed on Sep. 4, 2020.
Prior Publication US 2022/0072246 A1, Mar. 10, 2022
Int. Cl. A61M 16/00 (2006.01); G06N 20/00 (2019.01)
CPC A61M 16/0051 (2013.01) [A61M 16/0003 (2014.02); A61M 16/026 (2017.08); G06N 20/00 (2019.01); A61M 2230/04 (2013.01); A61M 2230/40 (2013.01)] 20 Claims
OG exemplary drawing
 
4. A method of adjusting ventilator settings to prevent an occurrence of a patient-ventilator asynchrony (PVA), comprising:
measuring, by one or more sensors associated with a ventilator operating in assist mode and using first ventilator settings, a number of breath attribute signals of a patient receiving respiration assistance from the ventilator;
executing, by a controller operatively coupled to the one or more sensors, program code stored in a non-transitory machine readable medium configured to generate a cardiogenic index from the number of breath attribute signals and configured to analyze at least the cardiogenic index to determine whether a PVA has occurred based on the cardiogenic index;
indicating, using an interface associated with the ventilator, an asynchrony detection after determining that a PVA has occurred;
issuing, using the controller, one or more preprogrammed recommended adjustments to the first ventilator settings to address the PVA that has occurred; and
adjusting the ventilator settings in accordance with the one or more preprogramed recommended adjustments;
wherein to generate the cardiogenic index comprises:
standardizing the number of breath attribute signals to produce a number of standardized breath signals;
summing the number of standardized breath signals to produce a cumulative breath signal such that a data value for a given x-axis value from each standardized breath signal is added to corresponding data values from the same given x-axis value from all other standardized breath signals;
generating a power spectrum of the cumulative breath signal;
normalizing power distribution values in the power spectrum that fall within a predetermined cardiogenic frequency range; and
producing a reconstructed cardiogenic signal by transforming the normalized power distribution values from the predetermined frequency range into a time domain signal.