US 12,268,784 B2
Polylactic acid microsphere, polylactic-co-glycolic acid microsphere and method of preparing the same
Ming-Thau Sheu, Taipei (TW); Yu-Ying Hsu, Taipei (TW); Yu-De Su, Taipei (TW); Yu-Hsuan Liu, Taipei (TW); and Pu-Sheng Wei, Taipei (TW)
Assigned to Taipei Medical University, Taipei (TW); and Panion & BF Biotech Inc., Taipei (TW)
Filed by Taipei Medical University, Taipei (TW); and Panion & BF Biotech Inc., Taipei (TW)
Filed on Dec. 27, 2023, as Appl. No. 18/397,342.
Application 18/397,342 is a continuation of application No. 17/219,179, filed on Mar. 31, 2021, granted, now 11,883,536.
Prior Publication US 2024/0122856 A1, Apr. 18, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/16 (2006.01); A61K 9/10 (2006.01); A61K 9/19 (2006.01); A61K 47/10 (2017.01); A61K 47/26 (2006.01); A61K 47/38 (2006.01)
CPC A61K 9/1682 (2013.01) [A61K 9/10 (2013.01); A61K 9/1647 (2013.01); A61K 9/19 (2013.01); A61K 47/10 (2013.01); A61K 47/26 (2013.01); A61K 47/38 (2013.01)] 7 Claims
 
1. A method of preparing high molecular polymer microspheres, comprising:
providing a first solution, wherein the first solution comprises a high molecular polymer and an organic solvent, wherein the organic solvent comprises dichloromethane, chloroform, ethyl acetate or a combination thereof, wherein a weight volume concentration of the high molecular polymer in the first solution is from 2.5% to 20% based on 100% by weight volume concentration of the first solution;
providing a second solution, wherein the second solution comprises polyvinyl alcohol, sodium carboxymethyl cellulose and an aqueous solution, wherein a weight volume concentration of polyvinyl alcohol in the second solution is from 0.5% to 2%, and a weight volume concentration of sodium carboxymethyl cellulose in the second solution is from 0.1% to 2% based on 100% by weight volume concentration of the second solution;
adding the first solution to the second solution, and at the same time, agitating the second solution until the high molecular polymer is solidified to form a plurality of high molecular polymer microspheres, wherein a volume ratio of the second solution to the first solution is from 5:1 to 100:1; and
collecting the plurality of high molecular polymer microspheres.