	US 12,268,780 B1
	Transparent water nanolipid fluid (DNLF) dispersions and method of preparation using a twin screw extruder
Eric Morrison, West Saint Paul, MN (US)
Filed by Eric Morrison, West Saint Paul, MN (US)
Filed on Oct. 8, 2021, as Appl. No. 17/497,819.
Claims priority of provisional application 63/089,342, filed on Oct. 8, 2020.
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/107 (2006.01); A61K 9/51 (2006.01); A61K 31/01 (2006.01); A61K 31/015 (2006.01); A61K 31/05 (2006.01); A61K 31/122 (2006.01); A61K 31/167 (2006.01); A61K 31/192 (2006.01); A61K 31/216 (2006.01); A61K 31/245 (2006.01); A61K 31/355 (2006.01); A61K 31/375 (2006.01); A61K 31/593 (2006.01); A61K 31/616 (2006.01); A61K 36/185 (2006.01); A61K 36/23 (2006.01); A61K 36/28 (2006.01); A61K 36/45 (2006.01); A61K 36/54 (2006.01); A61K 36/73 (2006.01); A61K 36/752 (2006.01); B01F 23/41 (2022.01); B01F 27/42 (2022.01); B01F 101/22 (2022.01)

CPC A61K 9/1075 (2013.01) [A61K 9/5123 (2013.01); A61K 9/5192 (2013.01); A61K 31/01 (2013.01); A61K 31/015 (2013.01); A61K 31/05 (2013.01); A61K 31/122 (2013.01); A61K 31/167 (2013.01); A61K 31/192 (2013.01); A61K 31/216 (2013.01); A61K 31/245 (2013.01); A61K 31/355 (2013.01); A61K 31/375 (2013.01); A61K 31/593 (2013.01); A61K 31/616 (2013.01); A61K 36/185 (2013.01); A61K 36/23 (2013.01); A61K 36/28 (2013.01); A61K 36/45 (2013.01); A61K 36/54 (2013.01); A61K 36/73 (2013.01); A61K 36/752 (2013.01); B01F 23/4105 (2022.01); B01F 23/4145 (2022.01); B01F 27/421 (2022.01); B01F 2101/22 (2022.01); B01F 2215/0431 (2013.01); B01F 2215/0472 (2013.01); B01F 2215/0481 (2013.01)]

23 Claims

1. A lipid nanoparticle dispersion comprising:

from 11.1 to 19.8 wt. % of one or more polyethoxylated high hydrophile-lipophile-balance (HLB) surfactants selected from the group consisting of laureth-23, ceteareth-20, ceteareth-30, steareth-40, PEG32 stearate, PEG75 stearate, PEG100 stearate, PEG15 hydroxy stearate, PEG40 hydrogenated castor oil, polysorbate 20, polysorbate 80, and combinations thereof;

from 3.3 to about 10.1 wt. % of one or more low hydrophile-lipophile-balance (HLB) surfactants selected from the group consisting of cetyl alcohol, glyceryl oleate, glyceryl stearate, glyceryl monolinoleate, oleic acid, stearic acid, sorbitan oleate, soy lecithin, and combinations thereof;

one or more water immiscible oils selected from the group consisting of medium chain triglyceride oil, coconut oil, isopropyl palmitate, isopropyl myristate, methyl decanoate, ethyl myristate, ethyl oleate, mineral oil, orange essential oil, cyclopentasiloxane, poly(dimethyl siloxane), hexadecane, propylene glycol dicaprylate, isododecane, isoeicosane, isohexadecane, soy biodiesel, jojoba oil, cocoyl caprylocaprate, C₁₀-C₁₃alkane, squalane, sunflower seed oil, and combinations thereof; and

water,

wherein the lipid nanoparticle dispersion has a lipophilic concentration greater than about 25%, a volume average particle size less than about 100 nm, and a turbidity less than 375 nephelometric turbidity units (NTU) at room temperature.