	US 12,268,778 B2
	Bifunctional nucleoside hydrogel, preparation method therefor and use thereof
Hang Zhao, Sichuan (CN); Xin Zeng, Sichuan (CN); Ning Ji, Sichuan (CN); Hui Feng, Sichuan (CN); Jiang Liu, Sichuan (CN); and Qianming Chen, Sichuan (CN)
Assigned to SICHUAN UNIVERSITY, Sichuan (CN)
Appl. No. 17/594,657
Filed by SICHUAN UNIVERSITY, Sichuan (CN)
PCT Filed May 31, 2019, PCT No. PCT/CN2019/089636 § 371(c)(1), (2) Date Oct. 25, 2021, PCT Pub. No. WO2020/215446, PCT Pub. Date Oct. 29, 2020.
Claims priority of application No. 201910340339.9 (CN), filed on Apr. 25, 2019.
Prior Publication US 2022/0218605 A1, Jul. 14, 2022
Int. Cl. A61K 9/06 (2006.01); A61K 47/24 (2006.01); A61P 35/00 (2006.01); C07H 23/00 (2006.01)

CPC A61K 9/06 (2013.01) [A61K 47/24 (2013.01); A61P 35/00 (2018.01); C07H 23/00 (2013.01)]

17 Claims

1. A bifunctional nucleoside hydrogel comprising cross-linked isoguanosine, guanosine, and borate, wherein said hydrogel is formed by cross-linking of isoguanosine, guanosine and borate in water or in an aqueous solution.