	US 12,268,775 B2
	Dispensing method for producing dissolvable unit dose film constructs
Scott D. Barnhart, York, PA (US); Eric Lakatosh, Red Lion, PA (US); William C. Baer, Harrisburg, PA (US); and Abraham Anonuevo, Rosedale, MD (US)
Assigned to ARx, LLC, Glen Rock, PA (US)
Filed by ARx, LLC, Glen Rock, PA (US)
Filed on Mar. 14, 2023, as Appl. No. 18/183,415.
Application 18/183,415 is a continuation of application No. 16/453,432, filed on Jun. 26, 2019, granted, now 11,648,197.
Claims priority of provisional application 62/692,003, filed on Jun. 29, 2018.
Claims priority of provisional application 62/691,327, filed on Jun. 28, 2018.
Prior Publication US 2023/0218513 A1, Jul. 13, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/00 (2006.01); A61K 8/02 (2006.01); A61K 9/70 (2006.01)

CPC A61K 9/006 (2013.01) [A61K 8/0233 (2013.01); A61K 9/0056 (2013.01); A61K 9/7007 (2013.01)]

20 Claims

1. A method for forming a dissolvable unit dose film construct, comprising:

providing a muco-adhesive composition including a muco-adhesive polymer matrix, the muco-adhesive polymer matrix comprising:

a first water-soluble polymer, a first water-dispersible polymer, a first water-swellable polymer, or combinations thereof; and

a first liquid carrier;

drying the muco-adhesive composition to remove at least a portion of the first liquid carrier, forming a muco-adhesive film substrate;

forming a composition for a first active layer, the composition including a first polymer matrix, the first polymer matrix comprising:

a second water-soluble polymer, a second water-dispersible polymer, a second water-swellable polymer, or combinations thereof;

a first active ingredient; and

a second liquid carrier,

wherein the composition for the first active layer has a viscosity of 1-300 cps at 1 sec⁻¹shear rate;

depositing the composition for the first active layer onto the muco-adhesive substrate; and

removing at least a portion of the second liquid carrier from the deposited composition for the first active layer to form a first dissolvable film active layer on the muco-adhesive substrate.