US 12,268,773 B2
Shear-thinning therapeutic composition, and related methods
Xiaochu Ding, Pittsburgh, PA (US); Jin Gao, Pittsburgh, PA (US); and Yadong Wang, Ithaca, NY (US)
Assigned to University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Filed by University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Filed on Jul. 19, 2021, as Appl. No. 17/379,147.
Application 17/379,147 is a continuation of application No. 16/333,627, granted, now 11,077,051, previously published as PCT/US2017/051791, filed on Sep. 15, 2017.
Claims priority of provisional application 62/394,991, filed on Sep. 15, 2016.
Prior Publication US 2021/0346284 A1, Nov. 11, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 31/727 (2006.01); A61K 38/18 (2006.01); A61K 47/02 (2006.01); A61K 47/24 (2006.01); A61K 47/36 (2006.01); A61L 27/10 (2006.01); A61L 27/20 (2006.01); A61L 27/44 (2006.01); A61L 27/50 (2006.01); A61L 27/52 (2006.01); A61L 27/54 (2006.01); C08J 3/075 (2006.01)
CPC A61K 9/0024 (2013.01) [A61K 9/06 (2013.01); A61K 31/727 (2013.01); A61K 38/1825 (2013.01); A61K 47/02 (2013.01); A61K 47/24 (2013.01); A61K 47/36 (2013.01); A61L 27/10 (2013.01); A61L 27/20 (2013.01); A61L 27/446 (2013.01); A61L 27/50 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); C08J 3/075 (2013.01); A61L 2300/414 (2013.01); A61L 2400/06 (2013.01); A61L 2430/34 (2013.01); C08J 2305/10 (2013.01)] 20 Claims
 
1. A shear-thinning therapeutic composition, comprising:
silicate platelets;
a gelling agent non-covalently linking the platelets to form a shear-thinning composition; and
a therapeutic agent that binds non-covalently to the gelling agent and that is complexed non-covalently with the gelling agent,
wherein the gelling agent is a sulfated or sulfamated polymer, a sulfated or sulfamated polysaccharide, a sulfated or sulfamated glycosaminoglycan, an anionic amino acid, or an anionic polypeptide.