US 12,268,770 B2
Use of cell membrane-bound signaling factors
Gabriel Nistor, Irvine, CA (US)
Assigned to AiVita Biomedical, Inc., Irvine, CA (US)
Filed by AiVita Biomedical, Inc., Irvine, CA (US)
Filed on Apr. 26, 2023, as Appl. No. 18/139,825.
Application 18/139,825 is a continuation of application No. 16/763,959, granted, now 11,666,522, previously published as PCT/US2018/061550, filed on Nov. 16, 2018.
Claims priority of provisional application 62/587,338, filed on Nov. 16, 2017.
Prior Publication US 2024/0299282 A1, Sep. 12, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/17 (2006.01); A61K 8/64 (2006.01); A61K 8/73 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 38/18 (2006.01); A61K 47/26 (2006.01); A61K 47/40 (2006.01); A61K 47/54 (2017.01); A61K 47/61 (2017.01); A61K 47/69 (2017.01); A61Q 7/00 (2006.01); C07K 14/47 (2006.01); C12N 5/00 (2006.01); C12N 5/0735 (2010.01); C12N 5/074 (2010.01)
CPC A61K 8/738 (2013.01) [A61K 8/64 (2013.01); A61K 9/0014 (2013.01); A61K 9/08 (2013.01); A61K 38/1709 (2013.01); A61K 38/18 (2013.01); A61K 47/26 (2013.01); A61K 47/40 (2013.01); A61K 47/543 (2017.08); A61K 47/61 (2017.08); A61K 47/6951 (2017.08); A61Q 7/00 (2013.01); C07K 14/4705 (2013.01); C12N 5/0018 (2013.01); C12N 5/0606 (2013.01); C12N 5/0607 (2013.01); A61K 2800/56 (2013.01); C12N 2500/34 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A method of promoting regeneration of a tissue in a subject, the method comprising:
a. administering a composition to the subject, the composition comprising a heterogeneous mixture of complexes comprising:
i. a first complex comprising a first cyclodextrin molecule and a Wingless (Wnt) protein that is covalently bound to a first cell membrane lipid; and
ii. a second complex comprising a second cyclodextrin molecule and a Hedgehog (Hh) protein that is covalently bound to a second cell membrane lipid.