US 12,268,756 B2
Biocompatible magnetic materials
Wen-Yuan Hsieh, Hsinchu (TW); Yuan-Hung Hsu, Hsinchu (TW); Chia-Wen Huang, Hsinchu (TW); Ming-Cheng Wei, Taoyuan (TW); Chih-Lung Chen, Taichung (TW); and Shian-Jy Wang, Hsinchu (TW)
Assigned to MegaPro Biomedical Co. Ltd., Hsinchu (TW)
Filed by MegaPro Biomedical Co., Ltd., Zhubei (TW)
Filed on Nov. 24, 2021, as Appl. No. 17/535,168.
Application 17/535,168 is a continuation of application No. 16/204,510, filed on Nov. 29, 2018, abandoned.
Claims priority of application No. 201810145800.0 (CN), filed on Feb. 12, 2018.
Prior Publication US 2022/0080057 A1, Mar. 17, 2022
Int. Cl. A61K 49/08 (2006.01); A61K 49/12 (2006.01); A61K 49/18 (2006.01)
CPC A61K 49/085 (2013.01) [A61K 49/126 (2013.01); A61K 49/1824 (2013.01); A61K 49/1839 (2013.01); A61K 49/186 (2013.01); A61K 49/1875 (2013.01)] 16 Claims
 
1. A biocompatible magnetic material comprising:
an iron oxide oleic acid nanoparticle; and
one or more biocompatible polymers, each having formula (I) below, covalently bonded to the iron oxide oleic acid nanoparticle:

OG Complex Work Unit Chemistry
in which
R is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 cycloalkyl, C1-C10 heterocycloalkyl, aryl, heteroaryl, a C1-C10 carbonyl group, or a C1-C10 amine group;
L is a linker;
x is 1 to 10; and
y is 5 to 1000, wherein the iron oxide oleic acid nanoparticle contains 4-10% Fe(II) ions relative to the total iron ions.