US 12,268,751 B2
Anti-αVβ6 antibodies and antibody-drug conjugates
Maureen Ryan, Bellevue, WA (US); Lori Westendorf, Snohomish, WA (US); Eric Bradley Meyer, Hayward, CA (US); and Heather Jean Kostner, Bothell, WA (US)
Assigned to Seagen Inc., Bothell, WA (US)
Filed by SEAGEN INC., Bothell, WA (US)
Filed on Oct. 18, 2023, as Appl. No. 18/489,216.
Application 18/489,216 is a division of application No. 17/112,533, filed on Dec. 4, 2020, granted, now 11,827,709.
Claims priority of provisional application 63/012,584, filed on Apr. 20, 2020.
Claims priority of provisional application 62/943,959, filed on Dec. 5, 2019.
Prior Publication US 2024/0076383 A1, Mar. 7, 2024
Int. Cl. A61K 47/68 (2017.01); A61K 38/07 (2006.01); A61K 45/06 (2006.01); A61K 47/54 (2017.01); A61K 47/65 (2017.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01)
CPC A61K 47/68031 (2023.08) [A61K 38/07 (2013.01); A61K 45/06 (2013.01); A61K 47/545 (2017.08); A61K 47/65 (2017.08); A61K 47/6849 (2017.08); C07K 16/2839 (2013.01); A61P 35/00 (2018.01); C07K 2317/24 (2013.01)] 15 Claims
 
1. A nucleic acid encoding a mature heavy chain variable region and/or a mature light chain variable region of an anti-avb6 antibody, or antigen-binding fragment thereof, wherein the antibody or antigen-binding fragment thereof comprises the mature heavy chain and the mature light chain variable region, wherein the heavy chain variable region comprises complementary determining regions (CDRs) comprising the amino acid sequences of SEQ ID NOs: 31, 32, and 33, and the mature light chain variable region comprises CDRs comprising the amino acid sequences of SEQ ID NOs: 37, 42, and 39.