US 12,268,746 B2
Polypeptides having anti-senescent effects and uses thereof
Alessandra Zonari, San Francisco, CA (US); Carolina Reis de Oliveira, San Francisco, CA (US); Edgar Andres Ochoa, San Francisco, CA (US); Juliana Lott de Carvalho, Brasilia (BR); Lear Brace, Oakland, CA (US); Mariana Boroni, Rio de Janeiro (BR); Mylieneth Guiang, San Francisco, CA (US); Octávio Franco, Campo Grande (BR); William Farias Porto, Ceilândia (BR); and Thuany de Alencar e Silva, Brasilia (BR)
Assigned to OneSkin, Inc., San Francisco, CA (US); Universidade Catolica de Brasilia, Aguas Claras-DF (BR); and Uniao Brasileira de Educacao Catolica, Brasilia, Brasilia-DF (BR)
Filed by OneSkin, Inc., San Francisco, CA (US); UNIVERSIDADE CATÓLICA DE BRASÍLIA, Águas Claras-DF (BR); and UNIÃO BRASILEIRA DE EDUCAÇÃO CATÓLICA, Brasília-DF (BR)
Filed on Jul. 22, 2020, as Appl. No. 16/936,177.
Claims priority of provisional application 62/877,164, filed on Jul. 22, 2019.
Prior Publication US 2021/0038729 A1, Feb. 11, 2021
Int. Cl. A61K 47/42 (2017.01); A61K 9/06 (2006.01); A61K 38/07 (2006.01); A61K 38/08 (2019.01); A61K 38/16 (2006.01); A61K 47/46 (2006.01); A61K 47/55 (2017.01); C07K 7/06 (2006.01)
CPC A61K 47/42 (2013.01) [A61K 9/06 (2013.01); A61K 38/07 (2013.01); A61K 38/08 (2013.01); A61K 38/16 (2013.01); A61K 47/46 (2013.01); A61K 47/551 (2017.08); C07K 7/06 (2013.01)] 7 Claims
 
1. A topical composition comprising an isolated, synthetic, or recombinant polypeptide comprising WLKGI (SEQ ID NO:7), wherein the polypeptide comprises no more than 10 amino acids, wherein the topical composition is a cream, a transdermal patch, a topical patch, an ointment, an oil, a gel, a liquid, a powder, a lotion, a serum, an emulsion, a moisturizer, a foam, a face mask, a mousse, an aerosol, a spray, a cleanser, a toner, or a shampoo.