US 12,268,731 B2
Compositions comprising IL-15N72D-based molecules and bacillus calmette-guerin (BCG)
Bai Liu, Culver City, CA (US); Peter Rhode, Culver City, CA (US); Wenxin Xu, Culver City, CA (US); and Hing C. Wong, Culver City, CA (US)
Assigned to Altor Bioscience, LLC, Culver City, CA (US)
Filed by Altor Bioscience, LLC, Culver City, CA (US)
Filed on Apr. 18, 2024, as Appl. No. 18/639,678.
Application 18/063,871 is a division of application No. 17/825,959, filed on May 26, 2022, granted, now 11,679,144, issued on Jun. 20, 2023.
Application 15/921,512 is a division of application No. 14/755,989, filed on Jun. 30, 2015, granted, now 9,925,247, issued on Mar. 27, 2018.
Application 18/639,678 is a continuation of application No. 18/394,409, filed on Dec. 22, 2023.
Application 18/394,409 is a continuation of application No. 18/063,871, filed on Dec. 9, 2022, granted, now 11,890,323, issued on Feb. 6, 2024.
Application 17/825,959 is a continuation of application No. 16/925,138, filed on Jul. 9, 2020, granted, now 11,471,511, issued on Oct. 18, 2022.
Application 16/925,138 is a continuation of application No. 16/444,807, filed on Jun. 18, 2019, granted, now 11,173,191, issued on Nov. 16, 2021.
Application 16/444,807 is a continuation of application No. 15/921,512, filed on Mar. 14, 2018, granted, now 10,537,615, issued on Jan. 21, 2020.
Claims priority of provisional application 62/018,899, filed on Jun. 30, 2014.
Prior Publication US 2024/0252591 A1, Aug. 1, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/20 (2006.01); A61K 38/17 (2006.01); A61K 39/07 (2006.01); A61K 47/64 (2017.01); A61P 35/00 (2006.01); A61K 39/04 (2006.01); C07K 14/35 (2006.01); C07K 14/54 (2006.01); C07K 14/715 (2006.01); C07K 16/28 (2006.01)
CPC A61K 38/2086 (2013.01) [A61K 38/1793 (2013.01); A61K 47/6425 (2017.08); A61P 35/00 (2018.01); A61K 39/04 (2013.01); C07K 14/35 (2013.01); C07K 14/5443 (2013.01); C07K 14/7155 (2013.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); C07K 16/2887 (2013.01); C07K 16/2896 (2013.01); C07K 2317/732 (2013.01); C07K 2319/30 (2013.01); C07K 2319/32 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A pharmaceutical composition for treatment of bladder cancer in a human subject, the composition consisting essentially of:
i) 50 mg of Bacillus Calmette-Guerin (BCG); and
ii) 400 μg of an IL-15N72D:IL-15RαSu complex;
wherein the composition is formulated as a single dose for intravesical instillation.