US 12,268,722 B2
Compositions and uses of locally-applied antimicrobial synthetic cationic polypeptide(s) with enhanced performance and safety
Michael P. Bevilacqua, Carlsbad, CA (US); Daniel J. Huang, Carlsbad, CA (US); and Doug Looker, Carlsbad, CA (US)
Assigned to AMICROBE, INC., Carlsbad, CA (US)
Filed by AMICROBE, INC., Carlsbad, CA (US)
Filed on Mar. 8, 2022, as Appl. No. 17/654,021.
Application 17/654,021 is a continuation of application No. 16/500,288, granted, now 11,285,189, previously published as PCT/US2018/026322, filed on Apr. 5, 2018.
Claims priority of provisional application 62/482,630, filed on Apr. 6, 2017.
Prior Publication US 2023/0017994 A1, Jan. 19, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/02 (2006.01); A61K 9/06 (2006.01); A61K 9/08 (2006.01); A61K 45/06 (2006.01); A61L 26/00 (2006.01); A61P 31/04 (2006.01)
CPC A61K 38/02 (2013.01) [A61K 9/06 (2013.01); A61K 9/08 (2013.01); A61K 45/06 (2013.01); A61L 26/0047 (2013.01); A61P 31/04 (2018.01); A61L 2300/252 (2013.01); A61L 2300/404 (2013.01)] 17 Claims
 
1. An antimicrobial pharmaceutical composition, comprising:
an aqueous carrier; and
at least one antimicrobial synthetic cationic polypeptide(s) dispersed in the aqueous carrier at a concentration in the range of about 0.01% to about 5%, by weight based on total weight of the antimicrobial pharmaceutical composition;
wherein:
the at least one antimicrobial synthetic cationic polypeptide(s) comprises at least 40 amino acid units;
the at least one antimicrobial synthetic cationic polypeptide(s) comprises at least one cationic segment with a plurality of positively charged amino acid units at neutral pH and a hydrophobic segment with a plurality of hydrophobic amino acid units;
the ratio of the length of the cationic segment to the length of the hydrophobic segment is between about 1.5 and about 6;
the at least one antimicrobial synthetic cationic polypeptide(s) at a concentration of 2 wt % in deionized water has a viscosity at 37° C. of 2 centistokes (cSt) or greater; and
the aqueous carrier, containing the antimicrobial synthetic cationic polypeptide(s) at 2 wt %, has a viscosity at 37° C. that is greater than that of the aqueous carrier containing albumin at 2 wt % in place of the at least one antimicrobial synthetic cationic polypeptide(s).