US 12,268,715 B2
Method for producing biological tissue-like structure
Hideyuki Hiyoshi, Kanagawa (JP); Taisuke Mochida, Kanagawa (JP); Noriko Yamazoe, Kanagawa (JP); Junji Yamaura, Kanagawa (JP); Taro Toyoda, Kyoto (JP); and Shuhei Konagaya, Kyoto (JP)
Assigned to Orizuru Therapeutics, Inc., Kanagawa (JP)
Appl. No. 17/602,421
Filed by Orizuru Therapeutics, Inc., Fujisawa (JP)
PCT Filed Apr. 9, 2020, PCT No. PCT/JP2020/016642
§ 371(c)(1), (2) Date Oct. 8, 2021,
PCT Pub. No. WO2020/209389, PCT Pub. Date Oct. 15, 2020.
Claims priority of application No. 2019-075100 (JP), filed on Apr. 10, 2019.
Prior Publication US 2022/0168357 A1, Jun. 2, 2022
Int. Cl. C12N 5/074 (2010.01); A61K 35/39 (2015.01); A61P 3/10 (2006.01); C12N 5/071 (2010.01)
CPC A61K 35/39 (2013.01) [A61P 3/10 (2018.01); C12N 5/0677 (2013.01); C12N 2506/45 (2013.01); C12N 2513/00 (2013.01); C12N 2533/56 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A composition comprising: a biocompatible material; and cells derived from human pluripotent stem cells, for use in a method for producing a biological tissue-like structure in a biological tissue of a host animal, wherein the cells derived from human pluripotent stem cells are dispersed in the biocompatible material,
wherein the cells derived from human pluripotent stem cells are insulin-producing cells and
wherein a proportion of Ki67-positive cells in the cells derived from human pluripotent stem cells is less than 1%.