US 12,268,713 B2
Methods of generating cross-linked protein foams in situ
Ishay Attar, Hof Carmel (IL)
Assigned to BIOCHANGE LTD., M.P. Hof Carmel (IL)
Filed by BIOCHANGE LTD., Hof Carmel (IL)
Filed on Sep. 9, 2022, as Appl. No. 17/930,872.
Application 16/706,300 is a division of application No. 15/563,712, granted, now 10,596,194, issued on Mar. 24, 2020, previously published as PCT/IB2016/000894, filed on Apr. 1, 2016.
Application 17/930,872 is a continuation of application No. 16/706,300, filed on Dec. 6, 2019, granted, now 11,439,663.
Claims priority of provisional application 62/142,738, filed on Apr. 3, 2015.
Claims priority of provisional application 62/142,713, filed on Apr. 3, 2015.
Claims priority of provisional application 62/142,732, filed on Apr. 3, 2015.
Claims priority of provisional application 62/142,725, filed on Apr. 3, 2015.
Claims priority of provisional application 62/142,715, filed on Apr. 3, 2015.
Prior Publication US 2023/0256014 A1, Aug. 17, 2023
Int. Cl. A61K 9/12 (2006.01); A61B 17/064 (2006.01); A61K 35/12 (2015.01); A61K 47/42 (2017.01); A61L 27/36 (2006.01); A61L 27/38 (2006.01)
CPC A61K 35/12 (2013.01) [A61B 17/064 (2013.01); A61K 9/122 (2013.01); A61K 47/42 (2013.01); A61L 27/3604 (2013.01); A61L 27/3843 (2013.01)] 20 Claims
 
1. A composition, comprising a cross-linkable protein,
wherein the cross-linkable protein comprises at least one RGD (Arg-Gly-Asp) motif,
wherein the cross-linkable protein is present in the composition in a range of 0.5 wt % to 25 wt % based on a total weight of the composition,
wherein the composition comprises a cross-linked porous scaffold,
wherein a non-toxic cross-linker is essentially eluted from the cross-linked porous scaffold,
wherein the cross-linked porous scaffold comprises a closed cell foam having a Young's modulus between 0.1 KPa-11 KPa.