US 12,268,705 B2
Use of polysaccharide for treating ST-elevation myocardial infarction and diseases of the digestion system
Peter Sugita, Surabaya (ID); Wiwiek Widyastuti Budiliantono, Surabaya (ID); and Aurelia Maxine Sugita, Surabaya (ID)
Assigned to PT. SAHABAT LINGKUNGAN HIDUP, Surabaya (ID)
Filed by PT. Sahabat Lingkungan Hidup, Surabaya (ID)
Filed on Aug. 9, 2023, as Appl. No. 18/232,135.
Application 18/232,135 is a continuation of application No. 17/194,916, filed on Mar. 8, 2021, granted, now 11,766,450.
Application 17/194,916 is a continuation of application No. 15/806,048, filed on Nov. 7, 2017, granted, now 10,940,162, issued on Mar. 9, 2021.
Claims priority of provisional application 62/553,647, filed on Sep. 1, 2017.
Claims priority of provisional application 62/419,174, filed on Nov. 8, 2016.
Prior Publication US 2024/0216417 A1, Jul. 4, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/716 (2006.01); A61K 36/074 (2006.01); A61P 1/00 (2006.01); A61P 1/04 (2006.01); A61P 9/10 (2006.01); A61P 29/00 (2006.01)
CPC A61K 31/716 (2013.01) [A61K 36/074 (2013.01); A61P 1/00 (2018.01); A61P 1/04 (2018.01); A61P 9/10 (2018.01); A61P 29/00 (2018.01)] 25 Claims
 
1. A method of treating ST-elevation myocardial infarction in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of β-1,3/1,6-D-glucan, or a pharmaceutically acceptable salt thereof, and one or more of additional therapeutic agents each independently selected from the group consisting of an angiotensin-converting enzyme inhibitor, an angiotensin II receptor blocker, a beta blocker, a diuretic, an aldosterone antagonist, and digoxin;
wherein the method further comprises identifying or having identified the subject as exhibiting abnormal expression of one or more cytokines, and wherein the therapeutically effective amount is obtained by measuring the expression changes of interleukin-6, tumor necrosis factor-α, and C-reactive protein between pre- and post-administration of the β-1,3/1,6-D-glucan.