US 12,268,666 B2
Spray-dried dispersions, formulations, and polymorphs of (S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide
Barbara J. Brandhuber, Boulder, CO (US); Lauren T. Brent, San Diego, CA (US); Charles Todd Eary, Longmont, CO (US); Andrew Kenna, San Diego, CA (US); Firas Khan, San Diego, CA (US); Vivian F. H. Renshaw, San Diego, CA (US); and Stacey Renee Spencer, Lyons, CO (US)
Assigned to Loxo Oncology, Inc., Indianapolis, IN (US)
Filed by Loxo Oncology, Inc., Indianapolis, IN (US)
Filed on Feb. 13, 2024, as Appl. No. 18/440,563.
Application 18/440,563 is a division of application No. 17/260,745, previously published as PCT/US2019/043937, filed on Jul. 29, 2019.
Claims priority of provisional application 62/769,308, filed on Nov. 19, 2018.
Claims priority of provisional application 62/729,855, filed on Sep. 11, 2018.
Claims priority of provisional application 62/712,861, filed on Jul. 31, 2018.
Prior Publication US 2024/0238253 A1, Jul. 18, 2024
Int. Cl. A61K 31/415 (2006.01); A61K 9/00 (2006.01); A61K 9/20 (2006.01); A61K 31/635 (2006.01); A61P 35/04 (2006.01); C07K 16/28 (2006.01)
CPC A61K 31/415 (2013.01) [A61K 9/0053 (2013.01); A61K 9/2009 (2013.01); A61K 9/2018 (2013.01); A61K 9/2054 (2013.01); A61K 9/2059 (2013.01); A61K 31/635 (2013.01); A61P 35/04 (2018.01); C07K 16/2887 (2013.01); C07B 2200/13 (2013.01)] 8 Claims
 
1. A spray-dried dispersion comprising a compound of Formula I:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof and one or more polymers selected from the group consisting of an HPMCAS polymer, an HPMC polymer, a vinylpyrrolidone-vinyl acetate copolymer, and a polyvinylpyrrolidone (PVP) polymer.