	US 12,268,657 B2
	Coenzyme Q10 composition, and preparation method and application thereof in cardio-protection
Linzhi Tang, Guangzhou (CN); Xinbao Mo, Guangzhou (CN); Jifu Zhang, Guangzhou (CN); Dong Si, Guangzhou (CN); Xianbiao Yang, Guangzhou (CN); Haoxin Yuan, Guangzhou (CN); Faquan Yang, Guangzhou (CN); and Simin Lv, Guangzhou (CN)
Assigned to Guangdong Runhe Biotechnology Co., Ltd, Guangzhou (CN)
Filed by Guangdong Runhe Biotechnology Co., Ltd, Guangzhou (CN)
Filed on Oct. 25, 2024, as Appl. No. 18/926,566.
Claims priority of application No. 202311401630.5 (CN), filed on Oct. 26, 2023.
Prior Publication US 2025/0041242 A1, Feb. 6, 2025
Int. Cl. A61K 31/122 (2006.01); A61K 9/70 (2006.01); A61K 47/34 (2017.01); A61K 47/36 (2006.01); A61P 9/10 (2006.01)

CPC A61K 31/122 (2013.01) [A61K 9/7007 (2013.01); A61K 47/34 (2013.01); A61K 47/36 (2013.01); A61P 9/10 (2018.01)]

3 Claims

1. A coenzyme Q₁₀slow-release drug, comprising:

an isolation layer; and

a drug layer;

wherein the coenzyme Q₁₀slow-release drug is prepared by layer-by-layer stacking of the isolation layer and the drug layer; the drug layer comprises coenzyme Q₁₀and a pharmaceutically acceptable carrier; the isolation layer is composed of a degradable gel; a diameter of the drug layer is not larger than that of the isolation layer; the pharmaceutically acceptable carrier is a mixture of hyaluronic acid and alginate in a weight ratio of 3:4-8; and the degradable gel is a mixture of chitosan and a polylactic acid-hydroxyacetic acid copolymer in a weight ratio of 5:1-4; and

the coenzyme Q₁₀slow-release drug is prepared through steps of:

(S1) laying the degradable gel on a mold followed by casting to form the isolation layer;

(S2) mixing the coenzyme Q₁₀with the pharmaceutically acceptable carrier followed by spreading on the mold in step (S1) and casting to form the drug layer on the isolation layer; and

(S3) repeating steps (S1) and (S2); and bonding edges of adjacent isolation layers to obtain the coenzyme Q₁₀slow-release drug.