US 12,268,517 B2
Drop generating device
Charles Eric Hunter, Boone, NC (US); Bernard L. Ballou, Jr., Raleigh, NC (US); Jurgen Klaus Vollrath, Indian Trail, NC (US); Arthur H. Tew, Pinehurst, NC (US); Joshua Richard Brown, Hickory, NC (US); James Thornhill Leath, Burlington, NC (US); Nathan R. Faulks, Boone, NC (US); Bradley G. Johnson, Boone, NC (US); J. Sid Clements, Boone, NC (US); Phillip E. Russell, Boone, NC (US); John H. Hebrank, Durham, NC (US); Tsontcho Ianchulev, San Mateo, CA (US); Mark Packer, Eugene, OR (US); Troy Elliott, Raleigh, NC (US); Walter M. Fierson, Arcadia, CA (US); and Thomas J. Lindner, Corvallis, OR (US)
Assigned to Eyenovia, Inc., New York, NY (US)
Filed by Eyenovia, Inc., New York, NY (US)
Filed on May 13, 2021, as Appl. No. 17/319,401.
Application 17/319,401 is a continuation of application No. 16/107,716, filed on Aug. 21, 2018, granted, now 11,011,270.
Application 16/107,716 is a continuation of application No. 14/200,268, filed on Mar. 7, 2014, granted, now 10,154,923, issued on Dec. 18, 2018.
Application 14/200,268 is a continuation of application No. 13/184,484, filed on Jul. 15, 2011, granted, now 8,684,980, issued on Apr. 1, 2014.
Claims priority of provisional application 61/516,694, filed on Apr. 6, 2011.
Claims priority of provisional application 61/516,462, filed on Apr. 4, 2011.
Claims priority of provisional application 61/516,496, filed on Apr. 4, 2011.
Claims priority of provisional application 61/516,495, filed on Apr. 4, 2011.
Claims priority of provisional application 61/463,280, filed on Feb. 15, 2011.
Claims priority of provisional application 61/462,791, filed on Feb. 5, 2011.
Claims priority of provisional application 61/462,576, filed on Feb. 4, 2011.
Claims priority of provisional application 61/401,848, filed on Aug. 20, 2010.
Claims priority of provisional application 61/401,918, filed on Aug. 20, 2010.
Claims priority of provisional application 61/401,849, filed on Aug. 20, 2010.
Claims priority of provisional application 61/401,850, filed on Aug. 20, 2010.
Claims priority of provisional application 61/401,920, filed on Aug. 20, 2010.
Claims priority of provisional application 61/400,864, filed on Jul. 15, 2010.
Prior Publication US 2021/0407663 A1, Dec. 30, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/00 (2006.01); A61B 3/14 (2006.01); A61F 9/00 (2006.01); A61M 15/00 (2006.01); A61M 15/02 (2006.01); G16H 10/60 (2018.01); G16H 15/00 (2018.01); G16H 20/10 (2018.01); G16H 20/17 (2018.01); G16H 40/63 (2018.01); A61B 5/11 (2006.01); A61K 8/06 (2006.01); A61K 9/00 (2006.01); A61M 11/00 (2006.01); A61M 11/04 (2006.01); B05B 17/00 (2006.01); B05B 17/06 (2006.01); G16H 30/20 (2018.01); G16H 40/67 (2018.01); G16Z 99/00 (2019.01)
CPC A61B 5/4839 (2013.01) [A61B 3/14 (2013.01); A61F 9/0008 (2013.01); G16H 20/10 (2018.01); A61B 5/0059 (2013.01); A61B 5/0079 (2013.01); A61B 5/1103 (2013.01); A61F 9/00 (2013.01); A61F 9/0026 (2013.01); A61K 8/06 (2013.01); A61K 9/0048 (2013.01); A61M 11/00 (2013.01); A61M 11/005 (2013.01); A61M 11/042 (2014.02); A61M 15/008 (2014.02); A61M 15/0083 (2014.02); A61M 15/025 (2014.02); A61M 2205/0205 (2013.01); A61M 2205/0238 (2013.01); A61M 2205/3306 (2013.01); A61M 2205/3368 (2013.01); A61M 2205/3553 (2013.01); A61M 2205/3584 (2013.01); A61M 2205/3592 (2013.01); A61M 2205/36 (2013.01); A61M 2205/3673 (2013.01); A61M 2205/50 (2013.01); A61M 2205/581 (2013.01); A61M 2205/582 (2013.01); A61M 2205/583 (2013.01); A61M 2205/587 (2013.01); A61M 2205/8206 (2013.01); A61M 2209/086 (2013.01); A61M 2210/0612 (2013.01); B05B 17/0646 (2013.01); B05B 17/0661 (2013.01); B05B 17/0676 (2013.01); G16H 10/60 (2018.01); G16H 15/00 (2018.01); G16H 20/17 (2018.01); G16H 30/20 (2018.01); G16H 40/63 (2018.01); G16H 40/67 (2018.01); G16Z 99/00 (2019.02)] 13 Claims
OG exemplary drawing
 
1. A method of delivering fluid to an eye of a subject as an ejected stream of droplets, comprising:
generating the ejected stream of droplets via a droplet generating device, the droplet generating device including an ejector plate, the ejector plate including a plurality of openings formed through its thickness, and a piezoelectric actuator coupled to the ejector plate, the actuator being operable to oscillate the ejector plate at a frequency to thereby generate an ejected stream of droplets;
wherein the ejected stream of droplets is generated by actuating the piezoelectric actuator to oscillate the ejector plate, the droplets being ejected through the plurality of openings in the ejector plate; and
delivering the ejected stream of droplets to the eye of the subject,
wherein the ejected stream of droplets have an average ejected droplet diameter of greater than 20 microns and an average initial droplet ejecting velocity of between 0.5 m/s and 20 m/s such that at least about 85% of the mass of the ejected stream of droplets deposit on the eye during use.