US 12,268,510 B2
Apparatus and method for treating neurological disorders
Mattia Arlotti, Rimini (IT); Alberto Priori, Borgo Virgilio (IT); and Lorenzo Rossi, Trento (IT)
Assigned to Newronika S.p.A., Milan (IT)
Filed by Newronika S.R.L., Milan (IT)
Filed on Feb. 14, 2020, as Appl. No. 16/792,098.
Application 16/792,098 is a continuation of application No. 15/550,284, granted, now 10,596,379, previously published as PCT/IB2016/050735, filed on Feb. 11, 2016.
Claims priority of application No. MI2015A000219 (IT), filed on Feb. 16, 2015.
Prior Publication US 2020/0254261 A1, Aug. 13, 2020
Int. Cl. A61B 5/374 (2021.01); A61B 5/00 (2006.01); A61N 1/05 (2006.01); A61N 1/36 (2006.01); G16H 20/30 (2018.01)
CPC A61B 5/374 (2021.01) [A61B 5/4076 (2013.01); A61B 5/4836 (2013.01); A61N 1/0534 (2013.01); A61N 1/3606 (2013.01); A61N 1/36067 (2013.01); A61N 1/36139 (2013.01); A61N 1/36178 (2013.01); G16H 20/30 (2018.01); A61B 5/4082 (2013.01); A61B 5/7257 (2013.01); A61N 1/36064 (2013.01); A61N 1/36071 (2013.01); A61N 1/36082 (2013.01)] 8 Claims
OG exemplary drawing
 
1. An apparatus for treating neurological disorders comprising:
an electrode implantable in a patient;
a processing and stimulation device connected to the electrode, wherein the processing and stimulation device comprises:
a stimulation module adapted to generate a stimulation signal (Vstim) to be sent to the electrode, the stimulation signal (Vstim) having a plurality of stimulation parameters including a stimulation amplitude, stimulation duration, and stimulation frequency (Va, Vd, Vf),
an acquisition module configured to acquire neural activity signals from the patient and to calculate a power (PBF) of a beta frequency band of the acquired neural activity signals, and
a control module configured to:
adjust a stimulation parameter (Va, Vd, Vf) of the stimulation signal (Vstim) when the power (PBF) of the beta frequency band meets or exceeds an upper power value threshold (PBF2), wherein the upper power value threshold (PBF2) is a power of the beta frequency band of the patient's neural activity signals measured in the absence of pharmacological therapy (POFF);
adjust the stimulation parameter (Va, Vd, Vf) of the stimulation signal (Vstim) when the power (PBF) of the beta frequency band is at or below a lower power value threshold (PBF1), wherein the lower power value threshold (PBF1) is a power of the beta frequency band of the patient's neural activity signals measured in the presence of pharmacological therapy (PON); and
adjust the stimulation parameter (Va, Vd, Vf) of the stimulation signal (Vstim) according to a piecewise transfer function based on the power (PBF) of the beta frequency band, wherein the piecewise transfer function is:

OG Complex Work Unit Math
where:
Vi_HighThreshold is a maximum value of the stimulation parameter that provides a maximum clinical effect before side effects appear,
Vi_LowThreshold is a minimum value of the stimulation parameter that provides a minimum clinical effect,
POFFOFF is a power of the beta frequency band of the patient's neural activity signals measured in the absence of pharmacological therapy and in the absence of electrical stimulation,
PONON is a power of the beta frequency band of the patient's neural activity signals measured in the presence of pharmacological therapy and in the presence of electrical stimulation, and
Ui(PBF) is a law of variability that correlates a value of the stimulation parameter with the power (PBF) of the beta frequency band.