| CPC A61B 5/07 (2013.01) [A61B 5/0507 (2013.01); A61B 5/053 (2013.01); A61B 5/6853 (2013.01); A61B 5/6858 (2013.01)] | 20 Claims |

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1. A method for diagnosing a disease-state of tissue of a passageway in a body using a system that comprises an energy source, a controller and a medical device comprising an energy emitting portion that comprises a plurality of electrodes in contact with the tissue, the method comprising:
positioning a medical device in the passageway adjacent the tissue;
supplying an amount of low-power RF energy from the energy source to the energy emitting portion to diagnose the tissue, whereby a first portion of the amount of low-power RF energy is transmitted through the energy emitting portion to the tissue and a second portion of the amount of low-power RF energy is reflected back towards the medical device;
tuning a transmission line impedance of the system to match a predetermined load value that is estimated for healthy tissue;
monitoring a signal corresponding to the second portion for each of the plurality of electrodes after tuning the transmission line, wherein the second portion associated with individual electrodes is measured; and
analyzing the signal to determine a presence or absence of said disease-state tissue;
wherein the passageway is a mucosa-lined passageway and wherein the tissue that is diagnosed is submucosal tissue.
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