US 12,268,478 B2
Non-cerebral organ autoregulation status determination
Paul S. Addison, Edinburgh (GB); Dean Montgomery, Edinburgh (GB); and Andre Antunes, Edinburgh (GB)
Assigned to COVIDIEN LP, Mansfield, MA (US)
Filed by Covidien LP, Mansfield, MA (US)
Filed on Mar. 1, 2021, as Appl. No. 17/188,708.
Application 17/188,708 is a continuation of application No. 16/165,108, filed on Oct. 19, 2018, granted, now 10,932,673.
Prior Publication US 2021/0177275 A1, Jun. 17, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/0205 (2006.01); A61B 5/00 (2006.01); A61B 5/021 (2006.01); A61B 5/1455 (2006.01); A61B 5/20 (2006.01); G16H 10/60 (2018.01)
CPC A61B 5/0205 (2013.01) [A61B 5/201 (2013.01); A61B 5/42 (2013.01); A61B 5/7267 (2013.01); G16H 10/60 (2018.01); A61B 5/021 (2013.01); A61B 5/14553 (2013.01)] 31 Claims
OG exemplary drawing
 
1. A method comprising:
receiving, by processing circuitry, a blood pressure signal indicative of a blood pressure of a patient and an oxygen saturation signal indicative of an oxygen saturation of the patient;
determining, by the processing circuitry, a cerebral autoregulation status value based on the blood pressure signal and the oxygen saturation signal;
determining, by the processing circuitry, an adjustment value based on a relationship between the cerebral autoregulation status value and a non-cerebral autoregulation status value using a neural network algorithm comprising a plurality of nodes by:
inputting at least the cerebral autoregulation status value into the neural network algorithm;
iteratively evaluating an output of the neural network algorithm, wherein the output comprises a non-cerebral autoregulation status value estimate;
iteratively modifying at least one node parameter of the plurality of nodes based on the evaluation of the output of the neural network algorithm to generate a modified neural network algorithm; and
determining the adjustment value based on the modified neural network algorithm;
determining, by the processing circuitry, the non-cerebral autoregulation status value of the patient based on the cerebral autoregulation status value and the adjustment value; and
providing, by the processing circuitry and to an output device, a signal indicative of the non-cerebral autoregulation status value.