US 12,268,471 B2
Discrimination of tissues using a fast infrared probe
James Coe, Worthington, OH (US); Heather Allen, Columbus, OH (US); Charles Hitchcock, Upper Arlington, OH (US); and Edward W. Martin, Delaware, OH (US)
Assigned to Ohio State Innovation Foundation, Columbus, OH (US)
Filed by OHIO STATE INNOVATION FOUNDATION, Columbus, OH (US)
Filed on Apr. 18, 2024, as Appl. No. 18/639,245.
Application 18/639,245 is a continuation of application No. 18/139,722, filed on Apr. 26, 2023, granted, now 11,986,268.
Application 18/139,722 is a continuation of application No. 16/085,210, granted, now 11,678,802, issued on Jun. 20, 2023, previously published as PCT/US2017/022670, filed on Mar. 16, 2017.
Claims priority of provisional application 62/309,116, filed on Mar. 16, 2016.
Prior Publication US 2025/0017470 A1, Jan. 16, 2025
Int. Cl. A61B 5/00 (2006.01); G01J 3/42 (2006.01); G01N 21/3563 (2014.01); G01N 21/552 (2014.01); A61B 17/00 (2006.01); A61B 90/00 (2016.01)
CPC A61B 5/0075 (2013.01) [A61B 5/444 (2013.01); G01J 3/42 (2013.01); G01N 21/3563 (2013.01); G01N 21/552 (2013.01); A61B 2017/00061 (2013.01); A61B 2090/373 (2016.02); A61B 2505/05 (2013.01); A61B 2576/00 (2013.01); G01J 2003/425 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A system for discriminating tissue of a specimen of a subject using infrared (IR) light from an IR source, the system comprising:
a probe, in communication with the IR source via a fiber optic cable, wherein the probe is configured to obtain a portion of an IR spectrum from response light from the specimen in response to illumination of the specimen using a specified subset of IR wavelengths provided by the IR source over a first measurement time period;
an IR detector, couplable to the probe to detect a portion of the IR spectrum from the probe via the fiber optic cable; and
a computing device, comprising a processor and a memory in communication with the processor, the memory comprising computer-executable instructions, wherein the computing device is coupled to the IR detector to receive a signal representative of the detected portion of the IR spectrum, wherein said computer-executable instructions cause the processor to evaluate the obtained portion of the IR spectrum using one or more metrics to discriminate tissue using a trained learning model that is trained by analyzing response light from ground truth training samples at specified wavelengths, wherein the specified wavelengths are specified using a specified metric comprising a ratio of absorbances of the illuminating infrared light, and wherein tissue discrimination is performed by the computing device using the trained model and a Figure of Merit (FOM) that is based on the specified metric.