US 12,268,470 B2
Tissue detection system and methods for use thereof
Adnan S. Abbas, Santa Barbara, CA (US); and Roshan Shetty, Santa Barbara, CA (US)
Assigned to AI Biomed Corp., Santa Barbara, CA (US)
Filed by AI Biomed Corp., Santa Barbara, CA (US)
Filed on Oct. 25, 2023, as Appl. No. 18/493,937.
Application 18/493,937 is a continuation of application No. 16/828,803, filed on Mar. 24, 2020, granted, now 11,819,193.
Claims priority of provisional application 62/840,609, filed on Apr. 30, 2019.
Claims priority of provisional application 62/823,252, filed on Mar. 25, 2019.
Claims priority of provisional application 62/810,510, filed on Feb. 26, 2019.
Prior Publication US 2024/0049955 A1, Feb. 15, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 1/04 (2006.01); A61B 1/00 (2006.01); A61B 1/06 (2006.01); A61B 1/07 (2006.01); A61B 5/00 (2006.01)
CPC A61B 5/0071 (2013.01) [A61B 1/00009 (2013.01); A61B 1/00042 (2022.02); A61B 1/042 (2013.01); A61B 1/043 (2013.01); A61B 1/046 (2022.02); A61B 1/0638 (2013.01); A61B 1/0676 (2013.01); A61B 1/07 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A tissue detection system for locally stimulating fluorescence in a surgical region, and locating fluorescing areas in the surgical region, comprising:
a probe having a distal end configured for placement in contact or near contact with tissue material of interest;
at least one emitter and at least one emitter optical fiber, the at least one emitter configured to emit radiation for stimulating fluorescence in the tissue material of interest, the at least one emitter optical fiber coupled to the at least one emitter and extending through at least a portion of the probe;
at least one detector and at least one detector optical fiber, the at least one detector configured to detect fluorescence from the tissue material of interest within a local field of view, the at least one detector optical fiber coupled to the at least one detector and extending through at least a portion of the probe;
at least one camera separate from the probe and configured to detect fluorescence from the tissue material of interest within a wide field of view;
a controller and user interface coupled to the at least one emitter and configured to initiate operation of the at least one emitter, wherein distal ends of the at least one emitter optical fiber and the at least one detector optical fiber are collocated with the distal end of the probe, the at least one emitter optical fiber is configured to transfer the radiation from the at least one emitter to the distal end thereof, and the at least one detector optical fiber is configured to transfer a signal corresponding to the fluorescence from the tissue material of interest within the local field of view to the at least one detector; and
at least one modulator configured to modulate the radiation from at least one of the at least one emitter, and at least one demodulator configured to demodulate the signal corresponding to the fluorescence detected with the camera, wherein the signal corresponding to the fluorescence detected with the camera is demodulated by the demodulator on a pixel-by-pixel basis.