US 12,268,467 B2
Delivery system
James J. Yoo, Winston-Salem, NC (US); Anthony Atala, Winston-Salem, NC (US); Kyle W. Binder, Winston-Salem, NC (US); Weixin Zhao, Winston-Salem, NC (US); Dennis Dice, Yadkinville, NC (US); and Tao Xu, El Paso, TX (US)
Assigned to Wake Forest University Health Sciences, Winston-Salem, NC (US)
Filed by Wake Forest University Health Sciences, Winston-Salem, NC (US)
Filed on Nov. 25, 2019, as Appl. No. 16/694,017.
Application 16/694,017 is a continuation of application No. 12/986,812, filed on Jan. 7, 2011, granted, now 10,500,384.
Claims priority of provisional application 61/293,481, filed on Jan. 8, 2010.
Prior Publication US 2020/0101273 A1, Apr. 2, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/00 (2006.01); A61M 35/00 (2006.01); B41J 3/407 (2006.01); A61B 17/00 (2006.01); A61B 17/322 (2006.01); A61B 34/10 (2016.01)
CPC A61B 5/0064 (2013.01) [A61M 35/00 (2013.01); B41J 3/4073 (2013.01); A61B 5/445 (2013.01); A61B 2017/00747 (2013.01); A61B 2017/00969 (2013.01); A61B 2017/3225 (2013.01); A61B 2034/105 (2016.02); A61B 2034/108 (2016.02); A61M 35/20 (2019.05)] 20 Claims
OG exemplary drawing
 
1. A delivery system configured to control a three-dimensional optical detector and a printer operatively coupled to the three-dimensional optical detector, the delivery system comprising:
means for interpreting data from the optical detector to form a map of an area of interest of a patient;
means for transforming the map into a negative mold of the area of interest, wherein the mold comprises a plurality of Z-axis layers; and
means for overlaying each of the Z-axis layers of the negative mold with a series of lines, wherein the lines provide a path for control software to use to control the printer to deliver cells and/or compositions to the area of interest in situ based upon the map,
wherein the map is updated in real-time during delivery, by the printer, of the cells and/or compositions.