US 12,268,466 B2
System and method for assessment of neuro-inflammation using magnetic resonance imaging (MRI)
John-Paul Jaewoon Yu, Madison, WI (US)
Assigned to WISCONSIN ALUMNI RESEARCH FOUNDATION, Madison, WI (US)
Filed by Wisconsin Alumni Research Foundation, Madison, WI (US)
Filed on May 23, 2019, as Appl. No. 16/421,311.
Claims priority of provisional application 62/677,295, filed on May 29, 2018.
Prior Publication US 2019/0365229 A1, Dec. 5, 2019
Int. Cl. A61B 5/00 (2006.01); A61B 5/055 (2006.01); G01R 33/56 (2006.01); G01R 33/563 (2006.01)
CPC A61B 5/0042 (2013.01) [A61B 5/055 (2013.01); G01R 33/5608 (2013.01); G01R 33/56341 (2013.01); A61B 2576/026 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A magnetic resonance imaging (MRI) system comprising:
a magnet system configured to generate a polarizing magnetic field about at least a portion of a subject arranged in the MRI system;
a plurality of gradient coils configured to apply a gradient field to the polarizing magnetic field;
a radio frequency (RF) system configured to apply an excitation field to the subject and acquire MR image data from the subject;
a computer system programmed to:
control the plurality of gradient coils and the RF system to acquire neurite orientation dispersion and density imaging (NODDI) data from the subject;
process the NODDI data to determine an orientation dispersion index (ODI) component of the NODDI data;
assess the ODI component against one of a reference of neuro-inflammation or a prior ODI component acquired from the subject to distinguish an acute neuro-inflammation in the subject from chronic neuro-inflammation in the subject and quantify the acute neuro-inflammation or the chronic neuro-inflammation; and
generate a report indicating the quantified acute neuro-inflammation or chronic neuro-inflammation in the subject.