US 12,268,438 B2
Systems, devices, and methods for modulating renal nerve tissue
Robert Melder, Santa Rosa, CA (US); Martin Rothman, Santa Rosa, CA (US); and Stefan Tunev, Santa Rosa, CA (US)
Assigned to MEDTRONIC IRELAND MANUFACTURING UNLIMITED COMPANY, Dublin (IE)
Filed by Medtronic Ardian Luxembourg S.a.r.l., Luxembourg (LU)
Filed on Feb. 2, 2023, as Appl. No. 18/163,615.
Application 18/163,615 is a continuation of application No. 16/271,742, filed on Feb. 8, 2019, abandoned.
Application 16/271,742 is a continuation of application No. 14/713,604, filed on May 15, 2015, abandoned.
Claims priority of provisional application 62/136,136, filed on Mar. 20, 2015.
Claims priority of provisional application 62/103,460, filed on Jan. 14, 2015.
Claims priority of provisional application 62/064,929, filed on Oct. 16, 2014.
Claims priority of provisional application 62/049,058, filed on Sep. 11, 2014.
Claims priority of provisional application 62/042,832, filed on Aug. 28, 2014.
Claims priority of provisional application 61/994,595, filed on May 16, 2014.
Claims priority of provisional application 61/994,744, filed on May 16, 2014.
Prior Publication US 2023/0181251 A1, Jun. 15, 2023
Int. Cl. A61B 18/14 (2006.01); A61B 18/00 (2006.01); A61B 18/08 (2006.01); A61B 18/18 (2006.01); A61B 18/24 (2006.01); A61N 7/02 (2006.01)
CPC A61B 18/1492 (2013.01) [A61B 2018/00214 (2013.01); A61B 2018/00261 (2013.01); A61B 2018/00285 (2013.01); A61B 2018/00404 (2013.01); A61B 2018/00434 (2013.01); A61B 2018/00511 (2013.01); A61B 2018/00577 (2013.01); A61B 18/082 (2013.01); A61B 2018/1435 (2013.01); A61B 2018/1475 (2013.01); A61B 2018/1861 (2013.01); A61B 18/24 (2013.01); A61N 7/022 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method, comprising:
intravascularly advancing an elongate shaft of a catheter within renal vasculature of a patient, the catheter comprising a neuromodulation element comprising a plurality of electrodes;
executing a first modulating step using the neuromodulation element, the first modulating step comprising modulating first nerve tissue with a first neuromodulation energy level within an anatomical region extending about a main renal artery directly connected to an aorta of the patient and extending distally toward a kidney of the patient, wherein the first modulating step comprises forming a plurality of lesions within the anatomical region extending about the main renal artery;
executing a second modulating step using the neuromodulation element, the second modulating step comprising modulating second nerve tissue with a second neuromodulation energy level within an anatomical region extending about a branch vessel of the main renal artery, wherein the second nerve tissue excludes nerve fibers that diverge at least partially toward a non-renal destination, the first neuromodulation energy level being higher than the second neuromodulation energy level; and
repositioning the neuromodulation element within the renal vasculature between the first modulating step and the second modulating step such that the first modulating step and the second modulating step are sequentially executed in either order,
wherein the first neuromodulation energy level is delivered for a longer duration than the second neuromodulation energy level.