US 12,268,437 B2
Electric field application for single shot cardiac ablation by irreversible electroporation
Brendan E. Koop, Ham Lake, MN (US); Andrew L. De Kock, Ham Lake, MN (US); and Allan C. Shuros, St Paul, MN (US)
Assigned to Boston Scientific Scimed, Inc., Maple Grove, MN (US)
Filed by Boston Scientific Scimed Inc, Maple Grove, MN (US)
Filed on Jul. 21, 2021, as Appl. No. 17/381,953.
Claims priority of provisional application 63/056,017, filed on Jul. 24, 2020.
Prior Publication US 2022/0022952 A1, Jan. 27, 2022
Int. Cl. A61B 18/00 (2006.01); A61B 18/12 (2006.01); A61B 18/14 (2006.01)
CPC A61B 18/1492 (2013.01) [A61B 18/1206 (2013.01); A61B 2018/00577 (2013.01); A61B 2018/00613 (2013.01); A61B 2018/1253 (2013.01); A61B 2018/126 (2013.01); A61B 2018/1266 (2013.01); A61B 2018/1467 (2013.01)] 10 Claims
OG exemplary drawing
 
1. An electroporation ablation system for treating target tissue, the electroporation ablation system comprising:
an ablation catheter including:
a handle;
a shaft having a distal end and defining a longitudinal axis of the ablation catheter; and
an electroporation electrode arrangement at the distal end of the shaft and including a plurality of electrodes spatially arranged in a three-dimensional electrode structure about the longitudinal axis so as to generate a plurality of electric fields when a plurality of electrical pulse sequences are delivered to selected pairs of the plurality of electrodes, the plurality of electric fields including a first electric field having a first orientation relative to the longitudinal axis, and second electric field having a second orientation relative to the longitudinal axis, wherein at least one of the first orientation and second orientation is generally aligned with the longitudinal axis; and
an electroporation generator operatively coupled to the electroporation electrode arrangement and configured to selectively generate and deliver:
a first electrical pulse sequence to a first selected pair of electrodes to generate the first electric field, the first electrical pulse sequence comprising a plurality of first monophasic direct current (DC) pulses each having a first voltage and a first pulse length, wherein sequential first monophasic pulses have opposite polarities and are separated by a first predetermined inter-pulse delay; and
a second electrical pulse sequence to a second selected pair of electrodes to generate the second electric field, the second electrical pulse sequence comprising a plurality of second monophasic DC pulses each having a second voltage and a second pulse length, wherein the second voltage is lower than the first voltage, and wherein the second pulse length is greater than the first pulse length, and wherein sequential second monophasic DC pulses have opposite polarities and are separated by a second predetermined inter-pulse delay, and
wherein the electroporation generator is further configured to deliver each second monophasic DC pulse during one of the first inter-pulse delays.