US 12,268,355 B2
Discrimination of calculi and tissues with molecular chemical imaging
Jeffrey Cohen, Pittsburgh, PA (US); Patrick Treado, Pittsburgh, PA (US); Shona Stewart, Pittsburgh, PA (US); Heather Gomer, Sewickley, PA (US); Arash Samiei, Pittsburgh, PA (US); Alyssa Zrimsek, Pittsburgh, PA (US); and Jihang Wang, Sewickley, PA (US)
Assigned to CHEMIMAGE CORPORATION, Pittsburgh, PA (US)
Filed by CHEMIMAGE CORPORATION, Pittsburgh, PA (US)
Filed on Jan. 24, 2022, as Appl. No. 17/582,764.
Application 17/582,764 is a continuation of application No. 16/544,499, filed on Aug. 19, 2019, granted, now 11,229,400.
Claims priority of provisional application 62/719,462, filed on Aug. 17, 2018.
Prior Publication US 2022/0142457 A1, May 12, 2022
Int. Cl. A61B 1/00 (2006.01); A61B 1/06 (2006.01); A61B 5/00 (2006.01); G01N 21/25 (2006.01)
CPC A61B 1/000094 (2022.02) [A61B 1/0638 (2013.01); A61B 1/0646 (2013.01); A61B 5/4887 (2013.01); G01N 21/25 (2013.01)] 12 Claims
OG exemplary drawing
 
1. An imaging system for discriminating a calculus from surrounding tissue, comprising:
an illumination source configured to generate illuminating photons;
a first filter configured to filter a first plurality of illuminating photons and generate a first plurality of filtered photons comprising first multi-passband wavelengths and a second filter configured to filter a second plurality of illuminating photons and generate a second plurality of filtered photons comprising second multi-passband wavelengths, wherein a sample is illuminated with the first plurality of filtered photons and the second plurality of filtered photons to generate a first plurality of interacted photons and a second plurality of interacted photons, respectively; and
one or more detectors configured to detect the first plurality of interacted photons and the second plurality of interacted photons and generate one or more image data sets; and
a processor that processes the one or more image data sets and generates, using a multivariate algorithm, information related to a location of a calculus with respect to surrounding tissue,
wherein the processor is configured to generate one or more hypercubes from the one or more image data sets and generate a score image using the one or more hypercubes, and
wherein the first filter and the second filter are configured to filter the first plurality of illuminating photons and the second plurality of illuminating photons simultaneously.