US 11,946,861 B2
Methods of characterizing a urine sample
Nicholas D. Laude, Pflugerville, TX (US); William S. Edgemond, Round Rock, TX (US); and Keqin Gregg, Austin, TX (US)
Assigned to Genotox Laboratories, Austin, TX (US)
Filed by Genotox Laboratories, Austin, TX (US)
Filed on Aug. 2, 2021, as Appl. No. 17/391,876.
Application 17/391,876 is a continuation of application No. 16/564,170, filed on Sep. 9, 2019, granted, now 11,079,320.
Application 16/564,170 is a continuation of application No. 15/730,433, filed on Oct. 11, 2017, granted, now 10,451,544, issued on Oct. 22, 2019.
Claims priority of provisional application 62/406,692, filed on Oct. 11, 2016.
Prior Publication US 2022/0276156 A1, Sep. 1, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 21/31 (2006.01); G01N 21/64 (2006.01); G16H 50/20 (2018.01)
CPC G01N 21/3103 (2013.01) [G01N 21/314 (2013.01); G01N 21/3151 (2013.01); G01N 21/6486 (2013.01); G16H 50/20 (2018.01); C12Q 2537/165 (2013.01)] 26 Claims
OG exemplary drawing
 
1. A method of characterizing a urine sample from a subject, the method comprising:
(a) providing a urine sample from a subject;
(b) determining one or more of the light absorption, luminescence, phosphorescence, fluorescence, and chemiluminescence of the urine sample at two or more wavelengths of light;
(c) applying one or more eigenvectors derived from a principle component algorithm to a standardized dataset derived from the determined light absorption, luminescence, phosphorescence, fluorescence, and chemiluminescence of the urine sample to generate a Urine Characterization Index (UCI) comprising one or more values for corresponding principle component(s);
(d) characterizing a urine sample as a natural urine sample based on the UCI; and
(e) performing genetic analysis of genetic material present in the urine sample.