	US 11,946,048 B2
	Non-human papillomaviruses for gene delivery in vitro and in vivo
Thomas Grunwald, Leipzig (DE); and Lea Bayer, Leipzig (DE)
Assigned to FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V., Munich (DE); and ANGEWANDTEN FORSCHUNG E.V., Munich (DE)
Appl. No. 16/763,957
Filed by Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., Munich (DE)
PCT Filed Nov. 13, 2018, PCT No. PCT/EP2018/081102 § 371(c)(1), (2) Date May 13, 2020, PCT Pub. No. WO2019/096796, PCT Pub. Date May 23, 2019.
Claims priority of application No. 10 2017 220 276.9 (DE), filed on Nov. 14, 2017.
Prior Publication US 2020/0385718 A1, Dec. 10, 2020
Int. Cl. C12N 15/113 (2010.01); A61K 38/16 (2006.01); A61K 47/66 (2017.01); C07K 14/005 (2006.01)

CPC C12N 15/113 (2013.01) [A61K 38/162 (2013.01); A61K 47/66 (2017.08); C07K 14/005 (2013.01); C12N 2710/20022 (2013.01); C12N 2710/20023 (2013.01); C12N 2710/20042 (2013.01); C12N 2710/20045 (2013.01); C12N 2800/22 (2013.01)]

6 Claims

1. A non-human papilloma pseudovirus or virus-like particle comprising at least one codon-optimized nucleic acid sequence encoding a papilloma capsid protein for expression in eukaryotic cells or cell lines, wherein the codon-optimized nucleic acid sequence is as shown in SEQ ID NOS. 1 to 20.