	US 11,945,868 B2
	Antibody molecules to CD138 and uses thereof
Bharat Chaganty, Concord, MA (US); Boopathy Ramakrishnan, Braintree, MA (US); Hedy Adari-Hall, Sudbury, MA (US); Karthik Viswanathan, Acton, MA (US); James R. Myette, Waltham, MA (US); and Zachary Shriver, Winchester, MA (US)
Assigned to VISTERRA, INC., Waltham, MA (US)
Filed by VISTERRA, INC., Waltham, MA (US)
Filed on Oct. 2, 2018, as Appl. No. 16/149,854.
Claims priority of provisional application 62/725,880, filed on Aug. 31, 2018.
Claims priority of provisional application 62/566,936, filed on Oct. 2, 2017.
Prior Publication US 2019/0100588 A1, Apr. 4, 2019
Int. Cl. C07K 16/28 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); C12N 15/62 (2006.01); A61K 39/00 (2006.01)

CPC C07K 16/2818 (2013.01) [A61K 39/39558 (2013.01); A61P 35/00 (2018.01); C07K 16/2896 (2013.01); C12N 15/62 (2013.01); A61K 2039/572 (2013.01); C07K 2317/32 (2013.01); C07K 2317/34 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)]

37 Claims

1. An anti-CD138 antibody molecule comprising:

(a) a heavy chain variable region (VH), wherein the VH comprises three heavy chain complementarity determining regions (HCDR1, HCDR2, and HCDR3), wherein the VH comprises:

(i) an HCDR1 comprising the amino acid sequence of SEQ ID NO: 350, 355, or 356, an HCDR2 comprising the amino acid sequence of SEQ ID NO: 351, and an HCDR3 comprising the amino acid sequence of FVY; or

(ii) an HCDR1 comprising the amino acid sequence of SEQ ID NO: 380, an HCDR2 comprising the amino acid sequence of SEQ ID NO: 381 or 382, and an HCDR3 comprising the amino acid sequence of FVY; and

(b) a light chain variable region (VL), wherein the VL comprises three light chain complementarity determining regions (LCDR1, LCDR2, and LCDR3), wherein the VL comprises:

an LCDR1 comprising the amino acid sequence of SEQ ID NO: 352 or an amino acid sequence that differs by 1 conservative amino acid substitution therefrom; an LCDR2 comprising the amino acid sequence of SEQ ID NO: 353; and an LCDR3 comprising the amino acid sequence of SEQ ID NO: 354.