CPC C07K 14/71 (2013.01) [A61P 9/12 (2018.01); C07K 2319/30 (2013.01)] | 33 Claims |
1. A polypeptide comprising:
(a) an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant comprising the amino acid sequence that is at least 85% identical to the amino acid sequence of SEQ ID NO: 2, wherein the ActRIIB-ECD variant comprises a substitution F58Q relative to the human wild type ActRIIB-ECD of SEQ ID NO: 2;
(b) a peptide linker comprising at least 10 amino acids; and
(c) an immunoglobulin (Ig) Fc domain monomer.
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