US 11,945,848 B2
Chimeric inhibitor molecules of complement activation
Peter Garred, Charlottelund (DK); Tina Hummelshoj Glue, Soborg (DK); and Mikkel-Ole Skjodt, Frederiksberg C (DK)
Assigned to Omeros Corporation, Seattle, WA (US)
Filed by Omeros Corporation, Seattle, WA (US)
Filed on Aug. 9, 2022, as Appl. No. 17/818,583.
Application 15/729,924 is a division of application No. 13/582,814, granted, now 9,815,876, issued on Nov. 14, 2017, previously published as PCT/EP2011/053309, filed on Mar. 4, 2011.
Application 17/818,583 is a continuation of application No. 16/930,973, filed on Jul. 16, 2020, granted, now 11,453,709.
Application 16/930,973 is a continuation of application No. 15/729,924, filed on Oct. 11, 2017, granted, now 10,752,661, issued on Aug. 25, 2020.
Claims priority of provisional application 61/311,024, filed on Mar. 5, 2010.
Claims priority of application No. 10155621 (EP), filed on Mar. 5, 2010.
Prior Publication US 2023/0295252 A1, Sep. 21, 2023
Int. Cl. A61K 38/17 (2006.01); A61K 38/00 (2006.01); A61K 45/06 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); C07K 14/81 (2006.01)
CPC C07K 14/47 (2013.01) [A61K 38/1725 (2013.01); A61K 45/06 (2013.01); C07K 14/472 (2013.01); C07K 14/4726 (2013.01); C07K 14/70596 (2013.01); C07K 14/8121 (2013.01); H05K 999/99 (2013.01); A61K 38/00 (2013.01); C07K 2319/01 (2013.01); C07K 2319/02 (2013.01); C07K 2319/30 (2013.01); C07K 2319/70 (2013.01); Y02A 50/30 (2018.01)] 9 Claims
 
1. A method of treating a subject suffering from an autoimmune disorder comprising administering a composition comprising a chimeric molecule of a ficolin-associated polypeptide, wherein said chimeric molecule of a ficolin-associated polypeptide comprises: (a) a human ficolin-associated polypeptide comprising the amino acid sequence set forth in SEQ ID NO:1 or a variant thereof having at least 80% sequence identity to the amino acid sequence set forth in SEQ ID NO:1; and (b) an inhibitor of complement activation, wherein said inhibitor of complement activation is selected from the list consisting of Factor H (FH), GAS6, Protein S, C1-inhibitor (C1-inh), complement component 4 binding protein (C4 bp), Factor I (FI), CR1, DAF(CD55), CD59, CR2, or a fragment thereof that inhibits complement activation, or an immunoglobulin molecule or part thereof that is an inhibitor of complement activation, and wherein said chimeric molecule inhibits complement activation in a subject suffering from an autoimmune disorder, wherein said autoimmune disorder is selected from the group consisting of Addison's disease, autoimmune hemolytic anemia, autoimmune thyroiditis, Crohn's disease, Graves' disease, Guillain-Barre syndrome, systemic lupus erythematosus, lupus nephritis, multiple sclerosis, myasthenia gravis, psoriasis, primary biliary cirrhosis, rheumatoid arthritis, uveitis, asthma, atherosclerosis, type I diabetes, and allergies.