US 11,945,164 B2
Method for manufacturing microneedle biosensor
Yue Cui, Beijing (CN)
Assigned to PEKING UNIVERSITY
Filed by Peking University, Beijing (CN)
Filed on Sep. 14, 2022, as Appl. No. 17/944,216.
Claims priority of application No. 202111075848.7 (CN), filed on Sep. 14, 2021.
Prior Publication US 2023/0078221 A1, Mar. 16, 2023
Int. Cl. B33Y 10/00 (2015.01); B29C 64/30 (2017.01); B33Y 40/20 (2020.01); B33Y 80/00 (2015.01); B41M 3/00 (2006.01); G01N 27/30 (2006.01); G01N 27/327 (2006.01); B29L 31/00 (2006.01)
CPC B29C 64/30 (2017.08) [B33Y 10/00 (2014.12); B33Y 40/20 (2020.01); B33Y 80/00 (2014.12); B41M 3/006 (2013.01); G01N 27/308 (2013.01); G01N 27/3271 (2013.01); B29L 2031/752 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A method for manufacturing a microneedle biosensor, wherein the microneedle biosensor comprises a microneedle and a substrate, wherein one end of the microneedle is connected to the substrate, an outer surface of the microneedle is provided with a working electrode and a first electrode, an outer surface of the working electrode is provided with an enzyme, and an outer surface of the microneedle biosensor is covered with a biocompatible film; and the method for manufacturing the microneedle biosensor comprises:
manufacturing the substrate and the microneedle in an additive manufacturing simultaneously;
aerosol jet printing the working electrode and the first electrode on the outer surface of the microneedle, followed by drying;
aerosol jet printing the enzyme on the outer surface of the working electrode; and using biocompatible liquid for jet-printing, and drying the biocompatible liquid to form the biocompatible film.