US 11,944,971 B2
Sorting particles in a microfluidic device
Ravi Kapur, Sharon, MA (US); Kyle C. Smith, Cambridge, MA (US); and Mehmet Toner, Charlestown, MA (US)
Assigned to The General Hospital Corporation, Boston, MA (US)
Filed by The General Hospital Corporation, Boston, MA (US)
Filed on Apr. 30, 2021, as Appl. No. 17/245,770.
Application 15/891,579 is a division of application No. 14/931,223, filed on Nov. 3, 2015, granted, now 9,895,694, issued on Feb. 20, 2018.
Application 17/245,770 is a continuation of application No. 16/112,259, filed on Aug. 24, 2018, granted, now 11,027,280.
Application 16/112,259 is a continuation of application No. 15/891,579, filed on Feb. 8, 2018, granted, now 10,875,021, issued on Dec. 29, 2020.
Claims priority of provisional application 62/074,213, filed on Nov. 3, 2014.
Claims priority of provisional application 62/074,315, filed on Nov. 3, 2014.
Prior Publication US 2021/0252514 A1, Aug. 19, 2021
Int. Cl. B01L 3/00 (2006.01); A61K 35/28 (2015.01); G01N 1/40 (2006.01); G01N 15/00 (2006.01); G01N 15/02 (2006.01); G01N 15/06 (2006.01); G01N 15/14 (2006.01)
CPC B01L 3/502761 (2013.01) [A61K 35/28 (2013.01); B01L 3/502715 (2013.01); B01L 3/502746 (2013.01); B01L 3/502753 (2013.01); G01N 1/4077 (2013.01); G01N 15/0255 (2013.01); G01N 15/0618 (2013.01); G01N 15/1484 (2013.01); B01L 3/502776 (2013.01); B01L 2200/0631 (2013.01); B01L 2200/0647 (2013.01); B01L 2200/0652 (2013.01); B01L 2200/0668 (2013.01); B01L 2200/0684 (2013.01); B01L 2200/12 (2013.01); B01L 2300/0681 (2013.01); B01L 2300/0877 (2013.01); B01L 2300/185 (2013.01); B01L 2400/0409 (2013.01); B01L 2400/0415 (2013.01); B01L 2400/043 (2013.01); B01L 2400/0436 (2013.01); B01L 2400/0457 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/082 (2013.01); G01N 2001/4088 (2013.01); G01N 2015/0053 (2013.01); G01N 2015/0065 (2013.01); G01N 2015/0288 (2013.01); G01N 2015/1486 (2013.01); G01N 2015/149 (2013.01); G01N 2015/1493 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A microfluidic device, comprising:
a particle sorting region, comprising:
a first array of islands separating a first microfluidic channel from a second microfluidic channel parallel to the first microfluidic channel, wherein each island in the first array is separated from an adjacent island in the first array by an opening that fluidly couples the first microfluidic channel to the second microfluidic channel;
a second array of islands separating the first microfluidic channel from a third microfluidic channel, wherein each island in the second array is separated from an adjacent island in the second array by an opening that fluidly couples the first microfluidic channel to the third microfluidic channel;
wherein the first microfluidic channel, the second microfluidic channel, and the first array of islands are configured to decrease a fluidic resistance of the second microfluidic channel along a longitudinal direction of the particle sorting region relative to the fluidic resistance of the first microfluidic channel;
wherein the first microfluidic channel, the third microfluidic channel, and the second array of islands are configured to increase a fluidic resistance of the third microfluidic channel along the longitudinal direction of the particle sorting region relative to the fluidic resistance of the first microfluidic channel; and
wherein the first array of islands and the second array of islands are parallel to each other, and each array of islands is oriented in the longitudinal direction of the particle sorting region.