US 11,944,820 B2
Neurostimulation of mixed nerves
John Louis Parker, Artarmon (AU); and Gerrit Eduard Gmel, Artarmon (AU)
Assigned to Saluda Medical Pty Ltd, Artarmon (AU)
Appl. No. 17/050,788
Filed by Saluda Medical Pty Ltd, Artarmon (AU)
PCT Filed Apr. 29, 2019, PCT No. PCT/AU2019/050384
§ 371(c)(1), (2) Date Oct. 26, 2020,
PCT Pub. No. WO2019/204884, PCT Pub. Date Oct. 31, 2019.
Claims priority of application No. 2018901410 (AU), filed on Apr. 27, 2018.
Prior Publication US 2021/0121696 A1, Apr. 29, 2021
Int. Cl. A61N 1/36 (2006.01); A61N 1/05 (2006.01); G16H 20/40 (2018.01)
CPC A61N 1/36139 (2013.01) [A61N 1/0553 (2013.01); A61N 1/0556 (2013.01); A61N 1/36003 (2013.01); A61N 1/36007 (2013.01); A61N 1/3601 (2013.01); A61N 1/36064 (2013.01); A61N 1/36071 (2013.01); A61N 1/36096 (2013.01); A61N 1/36114 (2013.01); A61N 1/36157 (2013.01); A61N 1/36171 (2013.01); A61N 1/36175 (2013.01); G16H 20/40 (2018.01)] 37 Claims
OG exemplary drawing
 
1. A method of neurostimulation of a mixed nerve comprising a plurality of nerve fibre types, the method comprising:
positioning an implantable electrode array proximal to a mixed nerve comprising a plurality of nerve fibre types, the implantable electrode array comprising a plurality of electrodes;
delivering an electrical stimulus from at least one nominal stimulus electrode of the implantable electrode array, the electrical stimulus being delivered in accordance with a set of stimulus parameters;
obtaining from at least one nominal recording electrode of the implantable electrode array a recording of an electrophysiological response evoked by the electrical stimulus;
analysing the recording of the electrophysiological response by assessing one or more selected characteristics of the recording, and identifying from the assessed selected characteristics a level of recruitment of a first fibre type recruited by the electrical stimulus; and
refining the stimulus parameters in a manner to effect selective recruitment of first fibre types relative to other fibre types of the mixed nerve,
wherein the stimulus parameters are post-operatively refinable stimulus parameters.