	US 11,944,722 B2
	Hydrogels with dynamically adjustable mechanical properties
Eben Alsberg, Cleveland, OH (US); Oju Jeon, Cleveland, OH (US); and Tae-Hee Kim, Cleveland, OH (US)
Assigned to CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Filed by CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Filed on Sep. 14, 2021, as Appl. No. 17/474,985.
Application 17/474,985 is a continuation of application No. 16/107,774, filed on Aug. 21, 2018, granted, now 11,116,875, issued on Sep. 14, 2021.
Claims priority of provisional application 62/548,243, filed on Aug. 21, 2017.
Prior Publication US 2021/0402063 A1, Dec. 30, 2021
Int. Cl. A61L 24/04 (2006.01); A61L 24/00 (2006.01); A61L 27/20 (2006.01); A61L 27/26 (2006.01); A61L 27/36 (2006.01); A61L 27/38 (2006.01); A61L 27/44 (2006.01); A61L 27/52 (2006.01); A61L 27/54 (2006.01); A61L 27/58 (2006.01); C08B 37/00 (2006.01); C08G 65/00 (2006.01); C08H 1/06 (2006.01); C08L 5/04 (2006.01); C08L 89/06 (2006.01)

CPC A61L 27/44 (2013.01) [A61L 27/20 (2013.01); A61L 27/26 (2013.01); A61L 27/3608 (2013.01); A61L 27/3834 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); A61L 27/58 (2013.01); C08B 37/0084 (2013.01); C08G 65/002 (2013.01); C08H 1/06 (2013.01); C08L 5/04 (2013.01); C08L 89/06 (2013.01); A61L 2300/236 (2013.01); A61L 2300/252 (2013.01); A61L 2300/412 (2013.01); A61L 2300/414 (2013.01); A61L 2400/16 (2013.01); A61L 2430/40 (2013.01); C08L 2205/04 (2013.01); C08L 2312/00 (2013.01)]

12 Claims

1. A composition comprising: a dual crosslinkable hydrogel that comprises a plurality of polymer macromers that are crosslinked with a first agent and a second agent different than the first agent, wherein the polymer macromers are ionically crosslinkable with the second agent and the crosslinks formed using the second agent are reversible and repeatable to allow the mechanical properties of the hydrogel to be dynamically adjusted by increasing or decreasing crosslinking with the second agent.