	US 11,944,716 B2
	Particulate coated hydrogel microparticles
Eben Alsberg, Cleveland, OH (US); and Rui Tang, Solon, OH (US)
Assigned to CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Filed by CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Filed on Dec. 7, 2021, as Appl. No. 17/544,544.
Application 17/544,544 is a continuation of application No. 16/371,806, filed on Apr. 1, 2019, granted, now 11,191,871, issued on Dec. 7, 2021.
Claims priority of provisional application 62/650,611, filed on Mar. 30, 2018.
Prior Publication US 2022/0088268 A1, Mar. 24, 2022
Int. Cl. A61K 9/50 (2006.01); A61K 47/02 (2006.01); A61K 47/42 (2017.01); A61L 27/24 (2006.01); A61L 27/36 (2006.01); A61L 27/54 (2006.01); C07K 14/78 (2006.01); C12N 5/00 (2006.01); B82Y 5/00 (2011.01); B82Y 40/00 (2011.01); C08J 3/075 (2006.01)

CPC A61L 27/24 (2013.01) [A61K 9/50 (2013.01); A61K 9/5084 (2013.01); A61K 47/02 (2013.01); A61K 47/42 (2013.01); A61L 27/36 (2013.01); A61L 27/54 (2013.01); C07K 14/78 (2013.01); C12N 5/0068 (2013.01); A61K 9/501 (2013.01); B82Y 5/00 (2013.01); B82Y 40/00 (2013.01); C08J 3/075 (2013.01); C08J 2389/00 (2013.01); C12N 2533/54 (2013.01)]

4 Claims

1. A composition comprising:

a plurality of particulate coated hydrogel microparticles, each of the microparticles including a hydrogel inner core and a particulate shell defined by a plurality of solid, inorganic nanoparticles, the hydrogel inner core comprising gelatin and at least one bioactive agent, and the particulate shell inhibiting aggregation of the microparticles in an aqueous medium and being permeable to allow release of bioactive agents provided in the hydrogel inner core from the hydrogel inner core, wherein the microparticles have an average diameter of about 25 μm to about 500 μm, and

a plurality of cells, the cells being dispersed with the microparticles in the composition.