US 11,944,673 B2
Yeast-brachyury immunotherapeutic compositions
Claudia Palena, Potomac, MD (US); Zhimin Guo, Superior, CO (US); David Apelian, Boonton Township, NJ (US); and Jeffrey Schlom, Potomac, MD (US)
Assigned to The USA, as represented by the Secretary, Dept. of Health and Human Services, Bethesda, MD (US); and GlobeImmune, Inc., Louisville, CO (US)
Filed by GlobeImmune, Inc., Louisville, CO (US); and The USA, as represented by the Secretary, Dept. of Health and Human Services, Bethesda, MD (US)
Filed on Apr. 19, 2019, as Appl. No. 16/389,235.
Application 16/389,235 is a continuation of application No. 15/454,176, filed on Mar. 9, 2017, granted, now 10,363,294.
Application 15/454,176 is a continuation of application No. 14/926,372, filed on Oct. 29, 2015, granted, now 9,623,097, issued on Apr. 18, 2017.
Application 14/926,372 is a continuation of application No. 13/803,719, filed on Mar. 14, 2013, granted, now 9,198,941, issued on Dec. 1, 2015.
Application 13/803,719 is a continuation of application No. PCT/US2012/029636, filed on Mar. 19, 2012.
Claims priority of provisional application 61/453,656, filed on Mar. 17, 2011.
Prior Publication US 2019/0374624 A1, Dec. 12, 2019
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/00 (2006.01); A61K 36/064 (2006.01); A61K 38/17 (2006.01); A61K 45/06 (2006.01); A61N 5/10 (2006.01); C07K 14/435 (2006.01)
CPC A61K 39/0011 (2013.01) [A61K 36/064 (2013.01); A61K 38/17 (2013.01); A61K 45/06 (2013.01); A61N 5/10 (2013.01); C07K 14/435 (2013.01); A61K 2039/51 (2013.01); A61K 2039/545 (2013.01); A61K 2039/55511 (2013.01); A61K 2039/6006 (2013.01); C07K 2319/00 (2013.01)] 3 Claims
 
1. A method to prevent or delay the onset of a Brachyury-expressing cancer, comprising administering to an individual who is at risk of undergoing metastatic progression and wherein the individual has a pre-cancerous lesion, an immunotherapeutic composition comprising:
a) a yeast vehicle; and
b) a cancer antigen comprising a Brachyury antigen, wherein the Brachyury antigen comprises SEQ ID NO:6, positions 2-435 of SEQ ID NO:6, SEQ ID NO:18, or positions 2-435 of SEO ID NO:18.