	US 11,944,637 B2
	Biomaterials comprising hyaluronic acid binding peptides and extracellular matrix binding peptides for hyaluronic acid retention and tissue engineering applications
Anirudha Singh, Baltimore, MD (US); Shimon Unterman, Brookline, MA (US); Michael Corvelli, Baltimore, MD (US); and Jennifer Elisseeff, Baltimore, MD (US)
Assigned to THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US)
Filed by THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US)
Filed on Aug. 27, 2021, as Appl. No. 17/459,201.
Application 17/459,201 is a division of application No. 16/260,191, filed on Jan. 29, 2019, granted, now 11,135,240.
Application 16/260,191 is a division of application No. 14/906,111, granted, now 10,231,991, issued on Mar. 19, 2019, previously published as PCT/US2014/046796, filed on Jul. 16, 2014.
Claims priority of provisional application 61/856,167, filed on Jul. 19, 2013.
Prior Publication US 2022/0062324 A1, Mar. 3, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/728 (2006.01); A61K 9/00 (2006.01); A61K 38/08 (2019.01); A61K 38/10 (2006.01); A61K 47/60 (2017.01); A61K 47/69 (2017.01); A61L 27/20 (2006.01); A61L 27/22 (2006.01)

CPC A61K 31/728 (2013.01) [A61K 9/0019 (2013.01); A61K 9/0048 (2013.01); A61K 38/08 (2013.01); A61K 38/10 (2013.01); A61K 47/60 (2017.08); A61K 47/6957 (2017.08); A61L 27/20 (2013.01); A61L 27/227 (2013.01); A61L 2400/10 (2013.01); A61L 2400/18 (2013.01); A61L 2430/06 (2013.01); A61L 2430/16 (2013.01)]

8 Claims

1. A method for treating dry eye in a subject comprising administering to the eye of a subject in need thereof, an effective amount of the biomaterial composition a biomaterial comprising at least one biologically compatible polymer having one or more hyaluronic acid (HA) binding peptides (HABPep) selected from the group consisting of: i) RRDDGAHWQFNALTVR (SEQ ID NO: 1) or a conservative amino acid substitution thereof at a residue position other than 4, 5, 6, 9, 10 or 11, ii) CRRDDGAHWQFNALTVR (SEQ ID NO: 2) or a conservative amino acid substitution thereof at a residue position other than 4, 5, 6, 9, 10 or 11, iii) GAAWQFNALTVR (SEQ ID NO: 9) or a conservative amino acid substitution thereof at a residue position other than 4, 5, 6, 9, 10 or 11, iv) GAHWQFAALTVR (SEQ ID NO: 10) or a conservative amino acid substitution thereof at a residue position other than 4, 5, 6, 9, 10 or 11, and v) GAHWQFNALTVA (SEQ ID NO: 11) or a conservative amino acid substitution thereof at a residue position other than 4, 5, 6, 9, 10 or 11, covalently linked to the biologically compatible polymer, and one or more extracellular matrix binding peptides (ECMBPep) covalently linked to the biologically compatible polymer.