CPC A61K 31/65 (2013.01) [A61K 9/0019 (2013.01); A61K 47/02 (2013.01)] | 25 Claims |
1. An intravenous formulation comprising:
an aqueous solution of a single antibiotic ingredient and a magnesium cation;
wherein:
the single antibiotic ingredient is minocycline;
the molar ratio of the magnesium cation to the minocycline is greater than 4:1;
the formulation has a pH greater than 4 and less than 7; and
administration of the intravenous formulation results in reduced injection site hemolysis relative to intravenous administration of a control intravenous formulation that does not include magnesium.
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